Tenex and Lamotrigine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tenex (guanfacine hydrochloride) and Lamotrigine (lamotrigine). Common drug interactions include burning sensation among females and tic among males.

The phase IV clinical study analyzes what interactions people have when they take Tenex and Lamotrigine. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Tenex?

Tenex has active ingredients of guanfacine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,865 Tenex users. Check the latest studies of Tenex.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

On Jul, 19, 2026

18 people who take Tenex and Lamotrigine together, and have interactions are studied.

Tenex and Lamotrigine drug interactions.

What are the common drug interactions of Tenex and Lamotrigine, by gender? *:

female:

Burning sensation
Myalgia (muscle pain)
Neuralgia (pain in one or more nerves)
Dehydration (dryness resulting from the removal of water)
Fracture
Hallucination (an experience involving the perception of something not present)
Ill-defined disorder
Nasopharyngitis (inflammation of the nasopharynx)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tooth disorder (tooth disease)

male:

Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Abnormal behaviour
Anger
Anticonvulsant drug level decreased
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Decreased interest
Depressed mood
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

What are the common drug interactions of Tenex and Lamotrigine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug level decreased
Abnormal behaviour
Anger
Anticonvulsant drug level decreased
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Decreased interest
Depressed mood
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Disturbance in attention

10-19:

Abnormal weight gain
Emotional distress
Gynaecomastia (enlargement of the gland tissue of the male breast)
Restlessness (not able to rest)
Tardive dyskinesia (a disorder that involves involuntary movements)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Local swelling (swelling at the site of some application of substance or injury)
Rash

20-29:

Somnolence (a state of near-sleep, a strong desire for sleep)
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Incontinence (lack of moderation or self-control)
Mania (a state of abnormally elevated or irritable mood)
Rash macular (small, flat red spots)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased
Burning sensation
Myalgia (muscle pain)

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 22.22%
Abnormal Behavior: 3 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
Amino Acid Metabolism Disorder: 2 people, 11.11%
Muscle Spasms (muscle contraction): 2 people, 11.11%
Mania (a state of abnormally elevated or irritable mood): 2 people, 11.11%
Indigestion: 2 people, 11.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 11.11%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.56%
Apnea (temporary absence or cessation of breathing): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Tenex and Lamotrigine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously