Testosterone and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Testosterone (testosterone) and Naproxen (naproxen). Common drug interactions include bell's palsy among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Testosterone and Naproxen. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Testosterone?

Testosterone has active ingredients of testosterone. It is often used in testosterone. eHealthMe is studying from 6,457 Testosterone users. Check the latest studies of Testosterone.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,034 Naproxen users. Check the latest studies of Naproxen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

94 people who take Testosterone and Naproxen together, and have interactions are studied.

Testosterone and Naproxen drug interactions.

What are the common drug interactions of Testosterone and Naproxen, by gender? *:

female:

Bell's palsy (facial paralysis)
Blood pressure decreased
Blood pressure increased
Blood sodium decreased
Burning sensation
Cardiac flutter (abnormal heart rhythm)
Chest discomfort
Coagulopathy (blood's ability to clot is impaired)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Constipation

male:

Emotional distress
Anxiety
Renal failure (kidney dysfunction)
Amino acid level increased
Cataract cortical (it affects outer part of lens)
Lenticular opacities (swelling and opacity of the entire lens)
Meibomian gland dysfunction (dry eyes)
Visual impairment
Chest pain
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

What are the common drug interactions of Testosterone and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Insulin-like growth factor increased
Osteoma (a new piece of bone usually growing on another piece of bone, typically the skull. it is a benign tumour)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Spinal fracture (fracture in one of vertebrae)

20-29:

Foot fracture
Hyperkalaemia (damage to or disease of the kidney)
Anaemia of chronic disease
Bone density decreased
Chronic kidney disease
Emotional distress
Hypertension (high blood pressure)
Multiple fractures
Nephropathy (damage to or disease of a kidney)
Osteopenia (a condition where bone mineral density is lower than normal)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Fracture
Gait disturbance
Osteoporosis (bones weak and more likely to break)
Drug intolerance (drug sensitivity)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Influenza like illness

40-49:

Headache (pain in head)
Rocky mountain spotted fever (fever is caused by rickettsia rickettsii a tick bite fever)
Suicide attempt
Hypersensitivity
Memory impairment
Hypertension (high blood pressure)
Joint swelling
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Blood cholesterol increased

50-59:

Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatitis acute
Hyperkalaemia (damage to or disease of the kidney)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity
Hypersomnia (excessive daytime sleepiness (eds))
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
International normalised ratio increased

60+:

Amino acid level increased
Cataract cortical (it affects outer part of lens)
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Ear discomfort
Fall
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Labyrinthitis (inflammation of the labyrinth or inner ear)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Otitis externa (external ear infection)
Proctalgia (pain in the rectum)

What are the existing conditions these people have? *

High Blood Pressure: 22 people, 23.40%
Hiv Infection: 20 people, 21.28%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 19 people, 20.21%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 15.96%
Stress And Anxiety: 14 people, 14.89%
Depression: 13 people, 13.83%
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 12 people, 12.77%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 10.64%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 9 people, 9.57%
Muscle Spasms (muscle contraction): 9 people, 9.57%

* Approximation only. Some reports may have incomplete information.

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