Theo-dur and Acetaminophen drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Theo-dur (theophylline) and Acetaminophen (acetaminophen). Common drug interactions include peripheral swelling among females and dyspnoea among males.
The phase IV clinical study analyzes what interactions people have when they take Theo-dur and Acetaminophen. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.
What is Theo-dur?
Theo-dur has active ingredients of theophylline. It is often used in asthma. eHealthMe is studying from 4,451 Theo-dur users. Check the latest studies of Theo-dur.
What is Acetaminophen?
Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.
71 people who take Theo-dur and Acetaminophen together, and have interactions are studied.

What are the common drug interactions of Theo-Dur and Acetaminophen, by gender? *:
female:
- Peripheral swelling
- Abdominal discomfort
- Anaemia (lack of blood)
- Nausea (feeling of having an urge to vomit)
- Pneumonia
- Hypokalaemia (low potassium)
- Cellulitis (infection under the skin)
- Constipation
- Vomiting
- Anxiety
male:
- Dyspnoea (difficult or laboured respiration)
- Vomiting
- Drug abuser
- Drug toxicity
- Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
- Dyspepsia (indigestion)
- Fall
- Nocturia (the need to get up in the night to urinate)
- Pyrexia (fever)
- Urinary incontinence (inability to control the flow of urine and involuntary urination)
What are the common drug interactions of Theo-Dur and Acetaminophen, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Abnormal behaviour
- Acidosis (build-up of carbon dioxide in the blood)
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Encephalopathy (functioning of the brain is affected by some agent or condition)
- Erythema multiforme (a type of hypersensitivity reaction)
- Fall
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
- Mydriasis (a dilation of the pupil)
- Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
- Vascular purpura (haemorrhages in the skin and mucous membranes that result in the appearance of purplish spots or patches)
10-19:
- Vomiting
- Anaphylactic reaction (serious allergic reaction)
- Dizziness
- Hyperventilation
- Hypoaesthesia (reduced sense of touch or sensation)
- Nausea (feeling of having an urge to vomit)
- Oliguria (not enough urine)
- Pallor
- Tachypnoea (a condition of rapid breathing over 20 per minute)
- Tremor (trembling or shaking movements in one or more parts of your body)
20-29:
n/a
30-39:
- Arthralgia (joint pain)
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Cardiomegaly (increased size of heart than normal)
- Delirium (wild excitement)
- Diarrhoea
- Drug abuser
- Drug toxicity
- Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
- Dyspepsia (indigestion)
- Fall
40-49:
- Dyspnoea (difficult or laboured respiration)
- Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
- Weight increased
- Anaemia (lack of blood)
- Back pain
- Bipolar disorder (mood disorder)
- Candidiasis (candidiasis or thrush is a fungal infection)
- Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Drug hypersensitivity
50-59:
- Hepatic steatosis (fatty liver disease)
- Infection in an immunocompromised host
- Neurological symptom (symptoms of nervous system disease)
- Obesity (having too much body fat)
- Respiratory tract infection
- Speech disorder
- Abdominal pain upper
- Ascites (accumulation of fluid in the abdominal cavity)
- Cellulitis (infection under the skin)
- Change of bowel habit
60+:
- Hypertension (high blood pressure)
- Oedema peripheral (superficial swelling)
- Mobility decreased (ability to move is reduced)
- Peripheral swelling
- Abdominal discomfort
- Anaemia (lack of blood)
- Pneumonia
- Thrombocytopenia (decrease of platelets in blood)
- Disseminated intravascular coagulation (systemic activation of blood coagulation)
- Haemorrhage subcutaneous (bleeding from skin)
What are the existing conditions these people have? *
- Osteoporosis (bones weak and more likely to break): 20 people, 28.17%
- Constipation: 20 people, 28.17%
- Oedema Peripheral (superficial swelling): 19 people, 26.76%
- High Blood Pressure: 18 people, 25.35%
- Back Pain: 16 people, 22.54%
- Diabetes: 16 people, 22.54%
- Restless Leg Syndrome (a powerful urge to move your legs): 16 people, 22.54%
- Psoriasis (immune-mediated disease that affects the skin): 16 people, 22.54%
- Indigestion: 16 people, 22.54%
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 16 people, 22.54%
* Approximation only. Some reports may have incomplete information.
Do you take Theo-dur and Acetaminophen?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Theo-dur (4,451 reports)
- Acetaminophen (183,077 reports)
Browse all drug interactions of Theo-dur and Acetaminophen:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Theo-dur:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Acetaminophen:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Theo-dur and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Acetaminophen and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Korang-Yeboah M, Rahman Z, Shah D, Mohammad A, Wu S, Siddiqui A, Khan MA, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International journal of pharmaceutics, 2016 Feb .
- Dhaval MK, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International Journal of Pharmaceutics, 2016 Jan .
- Korang-Yeboah M, Rahman Z, Shah D, Mohammad A, Wu S, Siddiqui A, Khan MA, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International journal of pharmaceutics, 2016 Feb .
- Dhaval MK, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International Journal of Pharmaceutics, 2016 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on theophylline and acetaminophen (the active ingredients of Theo-dur and Acetaminophen, respectively), and Theo-dur and Acetaminophen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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