Tiazac and Keflex drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Tiazac (diltiazem hydrochloride) and Keflex (cephalexin). Common drug interactions include body tinea among females and angina unstable among males.
The phase IV clinical study analyzes what interactions people have when they take Tiazac and Keflex. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.
What is Tiazac?
Tiazac has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 4,761 Tiazac users. Check the latest studies of Tiazac.
What is Keflex?
Keflex has active ingredients of cephalexin. It is often used in infection. eHealthMe is studying from 15,844 Keflex users. Check the latest studies of Keflex.
20 people who take Tiazac and Keflex together, and have interactions are studied.

What are the common drug interactions of Tiazac and Keflex, by gender? *:
female:
- Body tinea (ringworm of the body)
- Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
- Diarrhoea
- Essential hypertension (primary hypertension)
- Facial palsy (paralysis of face nerve)
- Herpes simplex (herpes simplex is a common viral infection)
- Herpes simplex ophthalmic (eye infection is caused by a type of herpes simplex virus)
- Hordeolum (small collection of pus (abscess) on the eyelid)
- Otitis media acute (rapid inflammation of the middle ear)
- Pain
male:
- Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
- Dyspnoea (difficult or laboured respiration)
- Oedema peripheral (superficial swelling)
- Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
- Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
- Sleep disorder
- Suicidal ideation
- Suicide attempt
- Appetite disorder (abnormal eating habits)
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
What are the common drug interactions of Tiazac and Keflex, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Abscess (pus)
- Arthrodesis
- Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
- Body tinea (ringworm of the body)
- Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
- Depression
- Diarrhoea
- Essential hypertension (primary hypertension)
- Facial palsy (paralysis of face nerve)
- Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
30-39:
- Pain
- Abortion (termination of pregnancy)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Asthma
- Bronchitis acute (acute inflammation of the mucous membrane in the bronchial tubes)
- Chest pain
- Chest tightness
- Complications of maternal exposure to therapeutic drugs
- Depression
40-49:
- Hallucination, auditory (perceiving sounds without auditory stimulus)
- Headache (pain in head)
- Multiple drug overdose
- Oedema peripheral (superficial swelling)
- Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
- Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
- Sleep disorder
- Suicidal ideation
- Suicide attempt
- Appetite disorder (abnormal eating habits)
50-59:
- Chronic kidney disease
- Drug hypersensitivity
- Renal failure (kidney dysfunction)
- Renal injury (kidney injury)
60+:
- Chronic kidney disease
- Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
- Agitation (state of anxiety or nervous excitement)
- Anaemia (lack of blood)
- Anaemia megaloblastic (disorder of abnormally large red blood cells)
- Angina pectoris (chest pain due to ischemia of the heart muscle)
- Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
- Angioplasty
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Arrhythmia (irregular heartbeat)
What are the existing conditions these people have? *
- Pain: 8 people, 40.00%
- Cardiac Failure Congestive: 3 people, 15.00%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.00%
- Gastric Disorder (disease of stomach): 3 people, 15.00%
- Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 10.00%
- Back Pain: 2 people, 10.00%
- Insomnia (sleeplessness): 2 people, 10.00%
- Hypersensitivity: 2 people, 10.00%
- High Blood Cholesterol: 2 people, 10.00%
- Gout (uric acid crystals building up in the body): 2 people, 10.00%
* Approximation only. Some reports may have incomplete information.
Do you take Tiazac and Keflex?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Tiazac and Keflex:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Tiazac:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Keflex:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Tiazac and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Keflex and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Agrawal A, Rao M, Jasdanwala S, Mathur A, Eng M, "Cephalexin Induced Cholestatic Jaundice", Case reports in gastrointestinal medicine, 2014 Aug .
- Agrawal A, Rao M, Jasdanwala S, Mathur A, Eng M, "Cephalexin Induced Cholestatic Jaundice", Case reports in gastrointestinal medicine, 2014 Aug .
How the study uses the data?
The study uses data from the FDA. It is based on diltiazem hydrochloride and cephalexin (the active ingredients of Tiazac and Keflex, respectively), and Tiazac and Keflex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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