Tigan and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tigan (trimethobenzamide hydrochloride) and Simvastatin (simvastatin). Common drug interactions include anxiety among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Tigan and Simvastatin. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Tigan?

Tigan has active ingredients of trimethobenzamide hydrochloride. It is often used in nausea. eHealthMe is studying from 1,904 Tigan users. Check the latest studies of Tigan.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

68 people who take Tigan and Simvastatin together, and have interactions are studied.

Tigan and Simvastatin drug interactions.

What are the common drug interactions of Tigan and Simvastatin, by gender? *:

female:

Anxiety
Constipation
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Malaise (a feeling of general discomfort or uneasiness)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Neuralgia (pain in one or more nerves)
Osteoporosis (bones weak and more likely to break)
Asthenia (weakness)
Body height decreased
Cardiac disorder

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting
Abdominal pain lower
Adrenal disorder
Anaemia (lack of blood)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Atelectasis (partial or complete collapse of the lung)
Balance disorder

What are the common drug interactions of Tigan and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Accidental exposure
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dysarthria (speech disorder)
Fall
Hypersomnia (excessive daytime sleepiness (eds))
Lip injury
Memory impairment

50-59:

Cardiac disorder
Constipation
Dry mouth
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Feeding disorder (when children refuse to eat certain food groups)
Fungal infection
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Lung disorder (lung disease)
Malaise (a feeling of general discomfort or uneasiness)
Neck pain

60+:

Dizziness
Vomiting
Pain
Abdominal tenderness
Asthenia (weakness)
Constipation
Dyskinesia (abnormality or impairment of voluntary movement)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Extrasystoles
Gastroenteritis (inflammation of stomach and intestine)

What are the existing conditions these people have? *

Parkinson's Disease: 24 people, 35.29%
High Blood Pressure: 15 people, 22.06%
Nausea And Vomiting: 14 people, 20.59%
Pain: 13 people, 19.12%
Diabetes: 12 people, 17.65%
Anaemia (lack of blood): 11 people, 16.18%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 10 people, 14.71%
Thyroid Diseases: 10 people, 14.71%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 10 people, 14.71%
Feeling Of Relaxation: 10 people, 14.71%

* Approximation only. Some reports may have incomplete information.

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