Tiopronin and Simvastatin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Tiopronin (tiopronin) and Simvastatin (simvastatin). Common drug interactions include completed suicide among females and cholecystitis among males.
The phase IV clinical study analyzes what interactions people have when they take Tiopronin and Simvastatin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.
What is Tiopronin?
Tiopronin has active ingredients of tiopronin. eHealthMe is studying from 321 Tiopronin users. Check the latest studies of Tiopronin.
What is Simvastatin?
Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.
21 people who take Tiopronin and Simvastatin together, and have interactions are studied.

What are the common drug interactions of Tiopronin and Simvastatin, by gender? *:
female:
- Completed suicide (act of taking one's own life)
- Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Dysgeusia (disorder of the sense of taste)
- Angioedema (rapid swelling of the dermis)
- Dyspnoea (difficult or laboured respiration)
- Swollen tongue (swelling of tongue)
- Seizure (abnormal excessive or synchronous neuronal activity in the brain)
- Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
- Vomiting
male:
- Cholecystitis (infection of gallbladder)
- Diarrhoea
- Rash
- Swelling
- Swelling face
- Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
- Palatal oedema (excessive accumulation of watery fluid in the roof of the mouth)
- Vulvovaginal swelling
- Lung infection
- Pneumonia
What are the common drug interactions of Tiopronin and Simvastatin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Rash
- Swelling
60+:
- Angioedema (rapid swelling of the dermis)
- Completed suicide (act of taking one's own life)
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Hypersensitivity
- Swelling face
- Swollen tongue (swelling of tongue)
- Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
- Palatal oedema (excessive accumulation of watery fluid in the roof of the mouth)
What are the existing conditions these people have? *
- Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 9 people, 42.86%
- High Blood Pressure: 7 people, 33.33%
- Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 23.81%
- Stress And Anxiety: 4 people, 19.05%
- Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream): 3 people, 14.29%
- Pain: 3 people, 14.29%
- Nausea (feeling of having an urge to vomit): 3 people, 14.29%
- Lung Cancer - Non-Small Cell (lung cancer): 3 people, 14.29%
- Heart Attack: 3 people, 14.29%
- Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 14.29%
* Approximation only. Some reports may have incomplete information.
Do you take Tiopronin and Simvastatin?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Tiopronin (321 reports)
- Simvastatin (256,970 reports)
Browse all drug interactions of Tiopronin and Simvastatin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Tiopronin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Simvastatin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Tiopronin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Simvastatin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on tiopronin and simvastatin (the active ingredients of Tiopronin and Simvastatin, respectively), and Tiopronin and Simvastatin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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