Topamax and Milk thistle drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topamax (topiramate) and Milk thistle (milk thistle). Common drug interactions include asthma among females and anal pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Topamax and Milk thistle. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,954 Topamax users. Check the latest studies of Topamax.

What is Milk thistle?

Milk thistle has active ingredients of milk thistle. It is often used in fatty liver. eHealthMe is studying from 5,057 Milk thistle users. Check the latest studies of Milk thistle.

On Jul, 14, 2026

24 people who take Topamax and Milk thistle together, and have interactions are studied.

Topamax and Milk thistle drug interactions.

What are the common drug interactions of Topamax and Milk Thistle, by gender? *:

female:

Asthma
Chest pain
Depression
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Anxiety
Back pain
Death
Dry mouth
Dysuria (painful or difficult urination)

male:

Anal pruritus (anal itching)
Anxiety
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Fall
Influenza like illness
Pain
Rash erythematous (redness of the skin)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Swollen tongue (swelling of tongue)
Tardive dyskinesia (a disorder that involves involuntary movements)

What are the common drug interactions of Topamax and Milk Thistle, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Depression
Dysuria (painful or difficult urination)
Nerve injury
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Therapeutic response decreased (less preventive response)
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Weight fluctuation

30-39:

Gait disturbance
Myalgia (muscle pain)

40-49:

Neuropathy peripheral (surface nerve damage)
Alopecia (absence of hair from areas of the body)
Anger
Aphasia (damage to the parts of the brain that control language)
Back pain
Chest pain
Chills (felling of cold)
Crying
Decreased interest
Depression

50-59:

Application site irritation
Application site reaction
Blood testosterone decreased
Diarrhoea
Drug ineffective
Hot flush (sudden feelings of heat)
Insomnia (sleeplessness)

60+:

Asthma
Knee arthroplasty
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Influenza like illness
Oedema (fluid collection in tissue)
Rash erythematous (redness of the skin)
Seasonal allergy (allergic condition due to certain season)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vision blurred

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 25.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 16.67%
Pain: 4 people, 16.67%
Depression: 4 people, 16.67%
Stress And Anxiety: 3 people, 12.50%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 8.33%
Allergic Rhinitis: 2 people, 8.33%
Asthma: 2 people, 8.33%
Drowsiness: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Topamax and Milk thistle?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously