Topiramate and Cozaar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topiramate (topiramate) and Cozaar (losartan potassium). Common drug interactions include blood calcium increased among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Topiramate and Cozaar. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

What is Cozaar?

Cozaar has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 45,124 Cozaar users. Check the latest studies of Cozaar.

On Jul, 20, 2026

63 people who take Topiramate and Cozaar together, and have interactions are studied.

Topiramate and Cozaar drug interactions.

What are the common drug interactions of Topiramate and Cozaar, by gender? *:

female:

Blood calcium increased
Cardiac arrest
Cardiovascular disorder (heart diseases)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery bypass
Crying
Decreased activity
Chronic kidney disease
Depression

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Oral mucosal discolouration (change in colour of mucous membrane of mouth)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Secretion discharge
Swollen tongue (swelling of tongue)
Tongue coated
Prostate cancer
Renal injury (kidney injury)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the common drug interactions of Topiramate and Cozaar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Infusion related reaction
Mycobacterium avium complex infection
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Throat tightness
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Anxiety

50-59:

Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Pain
Pneumonia
Renal impairment (severely reduced kidney function)
Restlessness (not able to rest)
Chronic kidney disease
Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Chronic kidney disease
Prostate cancer
Vulvovaginal pain
Abdominal pain upper
Blood glucose increased
Bone pain
Diarrhoea
Heart rate increased
Hypotension (abnormally low blood pressure)
Joint swelling

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 25.40%
Pain: 13 people, 20.63%
High Blood Cholesterol: 12 people, 19.05%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 11.11%
Multiple Allergies (allergy to multiple agents): 7 people, 11.11%
Depression: 7 people, 11.11%
Diabetes: 6 people, 9.52%
Muscle Spasms (muscle contraction): 5 people, 7.94%
Infection: 5 people, 7.94%
Stress And Anxiety: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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