Tpn and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tpn (niacinamide; pyridoxine hydrochloride; tyrosine) and Soliris (eculizumab). Common drug interactions include nausea among females and pneumatosis intestinalis among males.

The phase IV clinical study analyzes what interactions people have when they take Tpn and Soliris. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Tpn?

Tpn has active ingredients of niacinamide; pyridoxine hydrochloride; tyrosine. eHealthMe is studying from 1,581 Tpn users. Check the latest studies of Tpn.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

On Jul, 16, 2026

11 people who take Tpn and Soliris together, and have interactions are studied.

What are the common drug interactions of Tpn and Soliris, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Colitis (inflammation of colon)
Contusion (a type of hematoma of tissue in which capillaries)
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Fall
Fluid overload (too much fluid in the blood)
Headache (pain in head)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Hyperkalaemia (damage to or disease of the kidney)

male:

Pneumatosis intestinalis (air or gas in an intestine)

What are the common drug interactions of Tpn and Soliris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Pneumatosis intestinalis (air or gas in an intestine)

10-19:

Aphagia (inability or refusal to swallow)
Chills (felling of cold)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Upper respiratory tract infection
Vomiting

20-29:

Blood bicarbonate decreased
Blood chloride increased
Device related infection
Drug ineffective
Fatigue (feeling of tiredness)
Haematocrit decreased
Hepatic enzyme increased
Peripheral swelling
Small intestinal obstruction (blockage in small intestine)
Staphylococcal infection (an infection with staphylococcus bacteria)

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Abdominal pain upper
Arteriosclerosis (thickening and hardening of arteries)
Fluid overload (too much fluid in the blood)
Headache (pain in head)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Hyperkalaemia (damage to or disease of the kidney)
Hypoxia (low oxygen in tissues)
Impaired gastric emptying
Middle ear effusion (fluid in middle ear)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the existing conditions these people have? *

Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 9 people, 81.82%
Pain: 5 people, 45.45%
Thrombocytopenia (decrease of platelets in blood): 2 people, 18.18%
Swallowing Difficulty: 2 people, 18.18%
Nausea (feeling of having an urge to vomit): 2 people, 18.18%
Indigestion: 2 people, 18.18%
Immunosuppressant Drug Level: 2 people, 18.18%
Urinary Tract Infection: 1 person, 9.09%
Stress And Anxiety: 1 person, 9.09%
Platelet Disorder: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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