Tramadol and Folex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Folex (methotrexate sodium). Common drug interactions include febrile bone marrow aplasia among females and empyema among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Folex. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Folex?

Folex has active ingredients of methotrexate sodium. eHealthMe is studying from 107 Folex users. Check the latest studies of Folex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

12 people who take Tramadol and Folex together, and have interactions are studied.

What are the common drug interactions of Tramadol and Folex, by gender? *:

female:

Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Febrile neutropenia (fever with reduced white blood cells)
Mucosal inflammation (infection of mucous membrane)
Weight decreased
Vomiting
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

male:

Empyema (collection of pus in a cavity in the body)
Fistula (an abnormal connection or passageway between two)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Tramadol and Folex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Febrile neutropenia (fever with reduced white blood cells)
Mucosal inflammation (infection of mucous membrane)
Weight decreased
Vomiting

20-29:

n/a

30-39:

n/a

40-49:

Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

n/a

60+:

Empyema (collection of pus in a cavity in the body)
Fistula (an abnormal connection or passageway between two)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the existing conditions these people have? *

Sarcoma Metastatic (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues spreads to other parts): 8 people, 66.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
Amylase Increased: 2 people, 16.67%
Anaemia (lack of blood): 2 people, 16.67%
Anaesthesia: 2 people, 16.67%
Cough: 2 people, 16.67%
Fever: 2 people, 16.67%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 16.67%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 16.67%
Infection: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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