Tranexamic acid and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tranexamic acid (tranexamic acid) and Synthroid (levothyroxine sodium). Common drug interactions include death among females and rib fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Tranexamic acid and Synthroid. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Tranexamic acid?

Tranexamic acid has active ingredients of tranexamic acid. It is often used in heavy or prolong menstrual bleeding. eHealthMe is studying from 8,687 Tranexamic acid users. Check the latest studies of Tranexamic acid.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,205 Synthroid users. Check the latest studies of Synthroid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

61 people who take Tranexamic acid and Synthroid together, and have interactions are studied.

Tranexamic acid and Synthroid drug interactions.

What are the common drug interactions of Tranexamic Acid and Synthroid, by gender? *:

female:

Death
Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatomegaly (abnormal enlargement of the liver)
Hospitalisation
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Pain
Procedural headache
Procedural nausea
Leiomyosarcoma (a very rare soft tissue sarcoma (cancer) that grows in muscle tissue)

male:

Rib fracture
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Depression
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Haemorrhage (bleeding)
Laryngeal disorder (disease of larynx related to voice)
Libido increased (increased sexual urge to have sex)
Nausea (feeling of having an urge to vomit)
Post procedural complication
Therapeutic response decreased (less preventive response)

What are the common drug interactions of Tranexamic Acid and Synthroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Lymphocyte count decreased
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Muscle spasms (muscle contraction)
Neck pain
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Poor venous access
Post procedural complication
Proteinuria (presence of protein in the urine)
Rash papular (redness with papule)

40-49:

Adenomyosis (presence of ectopic glandular tissue found in muscle)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fungal infection
Labyrinthitis (inflammation of the labyrinth or inner ear)
Leiomyoma (a noncancerous (benign) tumour made up mostly of smooth muscle cells)
Localised infection (infection at the single location)
Migraine (headache)
Muscle tightness

50-59:

Nausea (feeling of having an urge to vomit)
Haemorrhage (bleeding)
Abdominal pain
Angioedema (rapid swelling of the dermis)
Arthralgia (joint pain)
Cerebral haemorrhage (bleeding within the brain)
Diarrhoea
Disease progression
Renal impairment (severely reduced kidney function)
Uveitis (inflammation of the uvea)

60+:

Cardiac failure congestive
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Febrile neutropenia (fever with reduced white blood cells)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperhidrosis (abnormally increased sweating)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)

What are the existing conditions these people have? *

Hereditary Angioedema (recurrent episodes of severe swelling): 12 people, 19.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 16.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 16.39%
Hyperlipidaemia (presence of excess lipids in the blood): 8 people, 13.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 11.48%
Type 2 Diabetes: 6 people, 9.84%
High Blood Pressure: 6 people, 9.84%
Anaemia (lack of blood): 6 people, 9.84%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 8.20%
High Blood Cholesterol: 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

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