Tranxene and Seroquel drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Tranxene (clorazepate dipotassium) and Seroquel (quetiapine fumarate). Common drug interactions include suicidal ideation among females and diabetes mellitus among males.
The phase IV clinical study analyzes what interactions people have when they take Tranxene and Seroquel. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.
What is Tranxene?
Tranxene has active ingredients of clorazepate dipotassium. It is often used in stress and anxiety. eHealthMe is studying from 6,550 Tranxene users. Check the latest studies of Tranxene.
What is Seroquel?
Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.
84 people who take Tranxene and Seroquel together, and have interactions are studied.

What are the common drug interactions of Tranxene and Seroquel, by gender? *:
female:
- Suicidal ideation
- Abdominal pain upper
- Fall
- Adverse event
- Drug ineffective
- Gastric disorder (disease of stomach)
- Contusion (a type of hematoma of tissue in which capillaries)
- Dizziness
- Nerve injury
- Road traffic accident
male:
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Asthenia (weakness)
- Akathisia (a movement disorder characterized by a feeling of inner restlessness)
- Asthma
- Chest discomfort
- Depressed mood
- Disturbance in attention
- Dizziness
- Fall
- Hypercholesterolaemia (high levels of cholesterol in the blood)
What are the common drug interactions of Tranxene and Seroquel, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Decreased appetite
- Drug ineffective
- Weight gain poor
10-19:
- Dyskinesia (abnormality or impairment of voluntary movement)
- Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
- Hyperkinetic syndrome (attention deficit disorder)
20-29:
- Abdominal pain upper
- Affective disorder (mental disorder)
- Alcoholism (problems with alcohol)
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
- Asthenia (weakness)
- Blindness
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Diabetes mellitus inadequate control
- Dry mouth
30-39:
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Diarrhoea
- Dyspnoea (difficult or laboured respiration)
- Panic disorder
- Type 2 diabetes mellitus
- Vision blurred
- Weight increased
- Arthralgia (joint pain)
- Chest pain
- Cough
40-49:
- Type 2 diabetes mellitus
- Drug hypersensitivity
- Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
- Suicidal ideation
- Cardiac failure
- Cardiac failure congestive
- Cardiogenic shock (inadequate circulation of blood)
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Diarrhoea
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
50-59:
- Speech disorder
- Activities of daily living impaired
- Balance disorder
- Disturbance in attention
- Hypophagia (reduced food intake)
- Memory impairment
- Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
- Muscle spasms (muscle contraction)
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
60+:
- Type 2 diabetes mellitus
- Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)
- Haemorrhoids (a swollen vein or group of veins in the region of the anus)
- Headache (pain in head)
- Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
- Neuropathy peripheral (surface nerve damage)
- Pelvic pain
- Pneumonia
- Restless legs syndrome (a powerful urge to move your legs)
- Stress urinary incontinence (leak urine with things like coughing, sneezing or exercise)
What are the existing conditions these people have? *
- Depression: 20 people, 23.81%
- High Blood Pressure: 14 people, 16.67%
- Sleep Disorder: 10 people, 11.90%
- Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 10 people, 11.90%
- Pain: 8 people, 9.52%
- Insomnia (sleeplessness): 8 people, 9.52%
- Diabetes: 8 people, 9.52%
- Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 7 people, 8.33%
- Parkinson's Disease: 5 people, 5.95%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.95%
* Approximation only. Some reports may have incomplete information.
Do you take Tranxene and Seroquel?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Tranxene and Seroquel:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Tranxene:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Seroquel:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Tranxene and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Seroquel and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
How the study uses the data?
The study uses data from the FDA. It is based on clorazepate dipotassium and quetiapine fumarate (the active ingredients of Tranxene and Seroquel, respectively), and Tranxene and Seroquel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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