Trulicity and Glumetza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trulicity (dulaglutide) and Glumetza (metformin hydrochloride). Common drug interactions include abdominal pain upper among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Trulicity and Glumetza. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

What is Glumetza?

Glumetza has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 1,968 Glumetza users. Check the latest studies of Glumetza.

On Aug, 06, 2026

41 people who take Trulicity and Glumetza together, and have interactions are studied.

Trulicity and Glumetza drug interactions.

What are the common drug interactions of Trulicity and Glumetza, by gender? *:

female:

Abdominal pain upper
Diarrhoea
Anorectal discomfort
Cough
Malaise (a feeling of general discomfort or uneasiness)
Pruritus (severe itching of the skin)
Rhinorrhoea (watery mucus discharge from the nose)
Injection site pain
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Injection site erythema (redness at injection site)

male:

Nausea (feeling of having an urge to vomit)
Cellulitis (infection under the skin)
Blood triglycerides increased
Cystitis (inflammation of the wall of the bladder)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Gastric bypass
Hospitalisation
Injection site induration
Injection site pain

What are the common drug interactions of Trulicity and Glumetza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Increased appetite

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Limb injury
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Tendon injury
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Type 1 diabetes mellitus
Chronic kidney disease
Gastric bypass

50-59:

Blood glucose increased
Staphylococcal infection (an infection with staphylococcus bacteria)
Abdominal pain upper
Constipation
Diarrhoea
Fatigue (feeling of tiredness)
Blood bilirubin increased
Blood triglycerides increased
Pancreatitis acute (sudden inflammation of pancreas)
Pancreatitis chronic (chronic inflammation of pancreas)

60+:

Injection site pruritus (severe itching at injection site)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Impaired gastric emptying
Overdose
Sensation of foreign body
Abdominal pain lower
Anaphylactic reaction (serious allergic reaction)
Blood glucose decreased
Cystitis (inflammation of the wall of the bladder)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Type 2 Diabetes: 20 people, 48.78%
High Blood Cholesterol: 5 people, 12.20%
Depression: 5 people, 12.20%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.76%
Insomnia (sleeplessness): 3 people, 7.32%
Hypersensitivity: 3 people, 7.32%
High Blood Pressure: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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