Trulicity and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trulicity (dulaglutide) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include sepsis among females and blood glucose fluctuation among males.

The phase IV clinical study analyzes what interactions people have when they take Trulicity and Ziac. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

13 people who take Trulicity and Ziac together, and have interactions are studied.

What are the common drug interactions of Trulicity and Ziac, by gender? *:

female:

Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal distension
Abnormal loss of weight
Alopecia (absence of hair from areas of the body)
Constipation
Dehydration (dryness resulting from the removal of water)
Eructation (release of gas from the digestive tract)
Feeding disorder (when children refuse to eat certain food groups)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Blood glucose fluctuation
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

What are the common drug interactions of Trulicity and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal distension
Abnormal loss of weight
Alopecia (absence of hair from areas of the body)
Constipation
Dehydration (dryness resulting from the removal of water)
Eructation (release of gas from the digestive tract)
Feeding disorder (when children refuse to eat certain food groups)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Balance disorder
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Dizziness
Dysstasia (difficulty in standing)
Fatigue (feeling of tiredness)
Feeling jittery
General physical health deterioration (weak health status)
Pain
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Diabetes: 7 people, 53.85%
Thyroid Diseases: 6 people, 46.15%
High Blood Cholesterol: 6 people, 46.15%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 46.15%
Fluid Retention (an abnormal accumulation of fluid in the blood): 6 people, 46.15%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 6 people, 46.15%
Blood Pressure Abnormal: 6 people, 46.15%
Neuropathy Peripheral (surface nerve damage): 4 people, 30.77%
Type 2 Diabetes: 3 people, 23.08%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

Do you take Trulicity and Ziac?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously