Truvada and Amaryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Truvada (emtricitabine; tenofovir disoproxil fumarate) and Amaryl (glimepiride). Common drug interactions include anaemia among females and varices oesophageal among males.

The phase IV clinical study analyzes what interactions people have when they take Truvada and Amaryl. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

On Jul, 07, 2026

26 people who take Truvada and Amaryl together, and have interactions are studied.

What are the common drug interactions of Truvada and Amaryl, by gender? *:

female:

Anaemia (lack of blood)
Nephropathy toxic (damage to kidney due to toxins)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)

male:

Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)
Blood bilirubin increased
Hypoglycaemia (deficiency of glucose in the bloodstream)
Renal impairment (severely reduced kidney function)
Somnolence (a state of near-sleep, a strong desire for sleep)
Hodgkin's disease (cancer originating from white blood cells)
Oedema peripheral (superficial swelling)
Abdominal distension
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Truvada and Amaryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood bilirubin increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Lipoatrophy (localized loss of fat tissue)
Melaena (the passage of black, tarry stools)
Platelet count decreased
Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)
White blood cell count decreased

40-49:

Oedema peripheral (superficial swelling)
Abdominal distension
Beta 2 microglobulin urine increased
Beta-n-acetyl-d-glucosaminidase increased
Biliary colic
Blood glucose increased
Death
Hunger
Nausea (feeling of having an urge to vomit)
Oesophageal varices haemorrhage (bleeding from extremely dilated sub-mucosal veins in the lower third of the oesophagus)

50-59:

Somnolence (a state of near-sleep, a strong desire for sleep)
Hodgkin's disease (cancer originating from white blood cells)
Anaemia (lack of blood)
Blood chloride increased
Blood creatinine increased
Blood urea increased
Disease recurrence
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Blood glucose increased

60+:

Anaemia (lack of blood)
Nephropathy toxic (damage to kidney due to toxins)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)

What are the existing conditions these people have? *

Hepatitis C: 12 people, 46.15%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 46.15%
High Blood Pressure: 4 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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