Tylenol and Lubiprostone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol (acetaminophen) and Lubiprostone (lubiprostone). Common drug interactions include abdominal pain lower among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol and Lubiprostone. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,309 Tylenol users. Check the latest studies of Tylenol.

What is Lubiprostone?

Lubiprostone has active ingredients of lubiprostone. eHealthMe is studying from 957 Lubiprostone users. Check the latest studies of Lubiprostone.

On Jul, 11, 2026

34 people who take Tylenol and Lubiprostone together, and have interactions are studied.

Tylenol and Lubiprostone drug interactions.

What are the common drug interactions of Tylenol and Lubiprostone, by gender? *:

female:

Abdominal pain lower
Abnormal faeces (abnormal stool)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood creatinine increased
Blood potassium decreased
Blood pressure diastolic increased
Blood pressure increased
Blood urea increased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone pain

male:

Acute respiratory failure
Constipation
Atelectasis (partial or complete collapse of the lung)
Dyspnoea (difficult or laboured respiration)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cough
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain

What are the common drug interactions of Tylenol and Lubiprostone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Arthralgia (joint pain)
Diarrhoea
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Cough
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain
Pyrexia (fever)
Rhinovirus infection

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Nephrolithiasis (calculi in the kidneys)
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

40-49:

n/a

50-59:

Flushing (the warm, red condition of human skin)
Glycosylated haemoglobin increased
Hepatic enzyme increased
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Nausea (feeling of having an urge to vomit)
Oral discomfort (pain or irritation in mouth)
Psychological trauma
Respiratory tract infection
Weight decreased
Constipation

60+:

Dyspnoea (difficult or laboured respiration)
Acute respiratory failure
Alanine aminotransferase increased
Aspartate aminotransferase increased
Brain natriuretic peptide increased
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug intolerance (drug sensitivity)
Hangover
Hypervolaemia (abnormally increased volume of blood)
Hypoacusis (loss of hearing)

What are the existing conditions these people have? *

Depression: 12 people, 35.29%
Constipation: 12 people, 35.29%
High Blood Pressure: 12 people, 35.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 26.47%
Nausea (feeling of having an urge to vomit): 9 people, 26.47%
Stress And Anxiety: 8 people, 23.53%
Fever: 7 people, 20.59%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 17.65%
Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 5 people, 14.71%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 14.71%

* Approximation only. Some reports may have incomplete information.

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