Tylenol and Xibrom drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol (acetaminophen) and Xibrom (bromfenac sodium). Common drug interactions include chronic kidney disease among females and osteonecrosis of jaw among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol and Xibrom. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

What is Xibrom?

Xibrom has active ingredients of bromfenac sodium. eHealthMe is studying from 162 Xibrom users. Check the latest studies of Xibrom.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

11 people who take Tylenol and Xibrom together, and have interactions are studied.

What are the common drug interactions of Tylenol and Xibrom, by gender? *:

female:

Chronic kidney disease
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Urine output decreased
Vomiting
Renal injury (kidney injury)
Nephrogenic anaemia (anaemia due to kidney disease)

male:

Osteonecrosis of jaw (death of bone of jaw)

What are the common drug interactions of Tylenol and Xibrom, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Pyrexia (fever)
Urine output decreased
Abdominal pain
Agitation (state of anxiety or nervous excitement)
Dyspnoea (difficult or laboured respiration)

60+:

Chronic kidney disease
Renal injury (kidney injury)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Fat tissue increased
Muscle spasms (muscle contraction)
Osteonecrosis of jaw (death of bone of jaw)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 45.45%
High Blood Pressure: 3 people, 27.27%
Osteoporosis (bones weak and more likely to break): 2 people, 18.18%
Insomnia (sleeplessness): 2 people, 18.18%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 9.09%
Dyslipidaemia (abnormal amount of lipids): 1 person, 9.09%
Diabetes: 1 person, 9.09%
Depression: 1 person, 9.09%
Deficiency Anaemia: 1 person, 9.09%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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