Tylox and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylox (acetaminophen; oxycodone hydrochloride) and Ultram (tramadol hydrochloride). Common drug interactions include adverse drug reaction among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Tylox and Ultram. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Tylox?

Tylox has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 369 Tylox users. Check the latest studies of Tylox.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.



On Jul, 09, 2026

16 people who take Tylox and Ultram together, and have interactions are studied.

Tylox and Ultram drug interactions.

What are the common drug interactions of Tylox and Ultram, by gender? *:

female:

  1. Adverse drug reaction
  2. Drug hypersensitivity
  3. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  4. Drug ineffective
  5. Dyspnoea (difficult or laboured respiration)
  6. Fatigue (feeling of tiredness)
  7. Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
  8. Osteopenia (a condition where bone mineral density is lower than normal)
  9. Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
  10. Varicose vein (veins that have become enlarged and tortuous)

male:

  1. Drug dependence
  2. Overdose
  3. Depression
  4. Drug abuse
  5. Drug tolerance increased
  6. Eating disorder
  7. Euphoric mood (excessively happy but may become angry or irritable)
  8. Gait disturbance
  9. General physical health deterioration (weak health status)
  10. Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

What are the existing conditions these people have? *

  1. Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 6.25%
  2. Thyroid Diseases: 1 person, 6.25%
  3. Stress And Anxiety: 1 person, 6.25%
  4. Rickets (softening of bones): 1 person, 6.25%
  5. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.25%
  6. Muscle Spasms (muscle contraction): 1 person, 6.25%
  7. Mouth Ulcers: 1 person, 6.25%
  8. Itching: 1 person, 6.25%
  9. High Blood Cholesterol: 1 person, 6.25%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Tylox and Ultram?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Tylox and Ultram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ultram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tylox and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ultram and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride and tramadol hydrochloride (the active ingredients of Tylox and Ultram, respectively), and Tylox and Ultram (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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