Uloric and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Uloric (febuxostat) and Zanaflex (tizanidine hydrochloride). Common drug interactions include vomiting among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Uloric and Zanaflex. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Uloric?

Uloric has active ingredients of febuxostat. It is often used in gout. eHealthMe is studying from 8,067 Uloric users. Check the latest studies of Uloric.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Jul, 15, 2026

26 people who take Uloric and Zanaflex together, and have interactions are studied.

What are the common drug interactions of Uloric and Zanaflex, by gender? *:

female:

Vomiting
Back injury
Dizziness
Drug administration error
Fall
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Injection site erythema (redness at injection site)
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site rash
Injection site urticaria (rash of round, red welts on the skin at injection site)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Bradycardia (abnormally slow heart action)
Constipation
Death
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Dizziness

What are the common drug interactions of Uloric and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Drug administration error
Injection site extravasation (flow of (blood or lymph) from injection site)
Retching (strong involuntary effort to vomit)
Vomiting
Drug intolerance (drug sensitivity)
Injection site pain
Nausea (feeling of having an urge to vomit)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Back injury
Dizziness
Fall
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Injection site erythema (redness at injection site)
Injection site rash
Injection site urticaria (rash of round, red welts on the skin at injection site)
Pruritus (severe itching of the skin)

60+:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Fatigue (feeling of tiredness)
Feeding disorder (when children refuse to eat certain food groups)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Intestinal obstruction
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Renal impairment (severely reduced kidney function)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 5 people, 19.23%
High Blood Cholesterol: 4 people, 15.38%
High Blood Pressure: 4 people, 15.38%
Depression: 3 people, 11.54%
Diabetes: 3 people, 11.54%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 11.54%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.54%
Hyperkalemia (damage to or disease of the kidney): 2 people, 7.69%
Gastric Ulcer (stomach ulcer): 2 people, 7.69%
Headache (pain in head): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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