Ultracet and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultracet (acetaminophen; tramadol hydrochloride) and Sinemet (carbidopa; levodopa). Common drug interactions include muscle atrophy among females and pathological gambling among males.

The phase IV clinical study analyzes what interactions people have when they take Ultracet and Sinemet. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Ultracet?

Ultracet has active ingredients of acetaminophen; tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 6,351 Ultracet users. Check the latest studies of Ultracet.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 06, 2026

25 people who take Ultracet and Sinemet together, and have interactions are studied.

What are the common drug interactions of Ultracet and Sinemet, by gender? *:

female:

Muscle atrophy (a decrease in the mass of the muscle)
Muscular weakness (muscle weakness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nicotine dependence
Palpitations (feelings or sensations that your heart is pounding or racing)
Personality change
Personality disorder
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polyuria (production of too much dilute urine)

male:

Pathological gambling
Hyperphagia (an abnormal appetite for food)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Psychotic disorder
Depression
Sleep disorder
Confusional state
Somnolence (a state of near-sleep, a strong desire for sleep)
Adverse drug reaction
Anxiety

What are the common drug interactions of Ultracet and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Personality change
Personality disorder
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polyuria (production of too much dilute urine)
Precancerous skin lesion
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Somatisation disorder (a long-term (chronic) condition in which a person has physical symptoms that involve more than one part of the body)

60+:

Confusional state
Dyskinesia (abnormality or impairment of voluntary movement)
Difficulty in walking
Drug ineffective
Dysstasia (difficulty in standing)
Hallucination (an experience involving the perception of something not present)
Hyperhidrosis (abnormally increased sweating)
Hyperkalaemia (damage to or disease of the kidney)
Hypokinesia (decreased bodily movement)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)

What are the existing conditions these people have? *

Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 32.00%
Depression: 7 people, 28.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 24.00%
Insomnia (sleeplessness): 6 people, 24.00%
Nasal Discharge (discharge from nose): 5 people, 20.00%
Genital Herpes (herpes infection of genital): 5 people, 20.00%
Curvature Of The Penis: 5 people, 20.00%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 5 people, 20.00%
Agitation (state of anxiety or nervous excitement): 4 people, 16.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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