Unasyn and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Unasyn (ampicillin sodium; sulbactam sodium) and Naproxen (naproxen). Common drug interactions include chest pain among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Unasyn and Naproxen. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Unasyn?

Unasyn has active ingredients of ampicillin sodium; sulbactam sodium. eHealthMe is studying from 4,474 Unasyn users. Check the latest studies of Unasyn.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

21 people who take Unasyn and Naproxen together, and have interactions are studied.

What are the common drug interactions of Unasyn and Naproxen, by gender? *:

female:

Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Ligament sprain (ligament stretched)
Wound necrosis (damaged cell of wound)
Joint swelling
Skin necrosis (skin damage)
Abscess (pus)
Compression fracture (fracture due to pressure caused by injury)
Diarrhoea
Haematuria (presence of blood in urine)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Lung infection
Emotional distress
Fear
Impaired work ability
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Quality of life decreased
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Skeletal injury (bone and supporting muscle injury)

What are the common drug interactions of Unasyn and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Blood immunoglobulin m increased
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Death
Decreased activity
Emotional distress
Fear
Impaired work ability
Quality of life decreased
Renal failure (kidney dysfunction)

30-39:

Abdominal pain upper
Acute respiratory distress syndrome
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anisocytosis (patient's red blood cells are of unequal size)
Anxiety
Asthenia (weakness)
Beta 2 microglobulin increased
Blood calcium decreased
Blood glucose increased
Blood lactate dehydrogenase increased

40-49:

Cancer pain
Malignant ascites (a condition in which a person with cancer has an accumulation of fluid in the abdomen)
Ovarian cancer (cancer of ovary)

50-59:

Constipation
Depression
Dizziness
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)
Dysthymic disorder (mild chronic depression disorder)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Epistaxis (bleed from the nose)
Fall

60+:

Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Insomnia (sleeplessness)
Nocturia (the need to get up in the night to urinate)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 8 people, 38.10%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 8 people, 38.10%
Gastritis (inflammation of stomach): 3 people, 14.29%
Tumor Associated Fever: 2 people, 9.52%
Stable Angina (a constant chest pain): 2 people, 9.52%
Renal Cell Carcinoma (a kidney cancer): 2 people, 9.52%
Pneumonia: 2 people, 9.52%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 2 people, 9.52%
Hiv Infection: 2 people, 9.52%
Cardiac Failure: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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