Ursodiol and Flurbiprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ursodiol (ursodiol) and Flurbiprofen (flurbiprofen). Common drug interactions include hypokalaemia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Ursodiol and Flurbiprofen. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Ursodiol?

Ursodiol has active ingredients of ursodiol. It is often used in primary biliary cirrhosis. eHealthMe is studying from 19,061 Ursodiol users. Check the latest studies of Ursodiol.

What is Flurbiprofen?

Flurbiprofen has active ingredients of flurbiprofen. It is often used in rheumatoid arthritis. eHealthMe is studying from 2,677 Flurbiprofen users. Check the latest studies of Flurbiprofen.

On Jul, 20, 2026

53 people who take Ursodiol and Flurbiprofen together, and have interactions are studied.

Ursodiol and Flurbiprofen drug interactions.

What are the common drug interactions of Ursodiol and Flurbiprofen, by gender? *:

female:

Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Injection site haemorrhage (bleeding from injection site)
Neutropenia (an abnormally low number of neutrophils)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Renal failure (kidney dysfunction)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
C-reactive protein increased
Oedema (fluid collection in tissue)

male:

Pyrexia (fever)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Cellulitis (infection under the skin)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Epstein-barr virus associated lymphoproliferative disorder (lymphocytes are produced in excessive quantities associated with epstein-barr virus)
Febrile neutropenia (fever with reduced white blood cells)
Fungal infection
Hepatic failure (liver failure)
Post transplant lymphoproliferative disorder

What are the common drug interactions of Ursodiol and Flurbiprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
C-reactive protein increased
Oedema (fluid collection in tissue)
Alanine aminotransferase increased
Activated partial thromboplastin time prolonged
Eosinophil count increased
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Pain in extremity
Pyrexia (fever)
Aspartate aminotransferase increased

10-19:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypertension (high blood pressure)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Immune system disorder
Oedema (fluid collection in tissue)
Platelet count decreased
Renal failure (kidney dysfunction)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Venoocclusive liver disease (small veins in the liver are obstructed)

20-29:

Aspergillosis (an infection caused by a fungus called aspergillus)
Bacterial infection
Candidiasis (candidiasis or thrush is a fungal infection)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Cytomegalovirus infection
Liver disorder (liver diseases)
Pyrexia (fever)
Viral infection

30-39:

Cellulitis (infection under the skin)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Febrile neutropenia (fever with reduced white blood cells)
Fungal infection
Renal failure (kidney dysfunction)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)

40-49:

n/a

50-59:

Venoocclusive liver disease (small veins in the liver are obstructed)
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Diarrhoea
Hepatic failure (liver failure)
Cytomegalovirus test positive
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Cytomegalovirus antigen positive
Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Cytomegalovirus infection
Disseminated cytomegaloviral infection (group of herpes viruses infection)

60+:

Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Pyrexia (fever)
Hypoaesthesia (reduced sense of touch or sensation)
Liver carcinoma ruptured (ruptured liver cancer tumour)
Pleural effusion (water on the lungs)
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Renal failure acute (rapid kidney dysfunction)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Excoriation (to tear or wear off the skin of)
Febrile neutropenia (fever with reduced white blood cells)

What are the existing conditions these people have? *

Fever: 16 people, 30.19%
Constipation: 15 people, 28.30%
Gastritis (inflammation of stomach): 10 people, 18.87%
Bone Marrow Conditioning Regimen: 9 people, 16.98%
Nausea (feeling of having an urge to vomit): 9 people, 16.98%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 8 people, 15.09%
Insomnia (sleeplessness): 8 people, 15.09%
Infection: 8 people, 15.09%
Hyperammonaemia: 7 people, 13.21%
Diabetes: 7 people, 13.21%

* Approximation only. Some reports may have incomplete information.

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