Flexeril and Kayexalate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Kayexalate (sodium polystyrene sulfonate). Common drug interactions include diabetic vascular disorder among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Kayexalate. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Kayexalate?

Kayexalate has active ingredients of sodium polystyrene sulfonate. eHealthMe is studying from 5,004 Kayexalate users. Check the latest studies of Kayexalate.

On Jul, 20, 2026

18 people who take Flexeril and Kayexalate together, and have interactions are studied.

Flexeril and Kayexalate drug interactions.

What are the common drug interactions of Flexeril and Kayexalate, by gender? *:

female:

Diabetic vascular disorder (diseases of the blood vessels due to diabetes)
Diastolic dysfunction
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dizziness
Drug effect decreased
Drug intolerance (drug sensitivity)
Dyspnoea at rest (difficult or laboured breathing during rest)
Erythema infectiosum (infection that results in a mild rash on the face, trunk, and limbs)
Essential hypertension (primary hypertension)
Failure to thrive (inadequate weight gain and physical growth in children)

male:

Abdominal pain
Agitation (state of anxiety or nervous excitement)
Death
Dehydration (dryness resulting from the removal of water)
Delirium (wild excitement)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

What are the common drug interactions of Flexeril and Kayexalate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood pressure increased
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephrogenic fibrosing dermopathy (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pruritus (severe itching of the skin)
Renal failure (kidney dysfunction)
Superior vena caval occlusion (obstruction of blood flow through the superior vena cava)
Thrombosis (formation of a blood clot inside a blood vessel)

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

50-59:

Delirium (wild excitement)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysphagia (a condition in which swallowing is difficult or painful)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Excoriation (to tear or wear off the skin of)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)

60+:

Dyspnoea (difficult or laboured respiration)
Vomiting
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hyperkalaemia (damage to or disease of the kidney)
Hypotension (abnormally low blood pressure)
Ischaemic hepatitis (decreased blood supply to the liver resulting in injury to liver cells)
Mitral valve incompetence (inefficient heart valve)
Multi-organ failure (multisystem organ failure)
Nausea (feeling of having an urge to vomit)
Platelet count decreased

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 4 people, 22.22%
High Blood Pressure: 4 people, 22.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 22.22%
Depression: 4 people, 22.22%
Diabetes: 3 people, 16.67%
Stress And Anxiety: 3 people, 16.67%
Back Pain: 3 people, 16.67%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 16.67%
Oedema Peripheral (superficial swelling): 3 people, 16.67%
Neuropathy Peripheral (surface nerve damage): 3 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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