1. Home
  2. Analysis
  3. Vagifem
  4. Ogen

Vagifem and Ogen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vagifem (estradiol) and Ogen (estropipate). Common drug interactions include anxiety among females.

The phase IV clinical study analyzes what interactions people have when they take Vagifem and Ogen. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Vagifem?

Vagifem has active ingredients of estradiol. It is often used in vulvovaginal dryness. eHealthMe is studying from 6,263 Vagifem users. Check the latest studies of Vagifem.

What is Ogen?

Ogen has active ingredients of estropipate. eHealthMe is studying from 2,553 Ogen users. Check the latest studies of Ogen.

On Jul, 13, 2026

33 people who take Vagifem and Ogen together, and have interactions are studied.

Vagifem and Ogen drug interactions.

What are the common drug interactions of Vagifem and Ogen, by gender? *:

female:

  1. Anxiety
  2. Weight decreased
  3. Sinusitis (inflammation of sinus)
  4. Abdominal pain
  5. Anaemia (lack of blood)
  6. Blood disorder
  7. Breast cancer female
  8. Depression
  9. Diarrhoea
  10. Drug intolerance (drug sensitivity)

male:

n/a

What are the common drug interactions of Vagifem and Ogen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Anxiety
  2. Breast cancer female
  3. Oestrogen receptor assay positive
  4. Progesterone receptor assay positive
  5. Psychiatric symptom

50-59:

  1. Weight decreased
  2. Influenza
  3. Drug ineffective
  4. Gastroenteritis radiation (radiation induced inflammation of stomach and intestine)
  5. Abdominal pain
  6. Anaemia (lack of blood)
  7. Anxiety
  8. Blood disorder
  9. Depression
  10. Diarrhoea

60+:

  1. Anxiety
  2. Pain
  3. Arthropathy
  4. Bereavement reaction
  5. Blood cholesterol increased
  6. Blood triglycerides increased
  7. Breast cancer in situ
  8. Cardiac disorder
  9. Cardiovascular disorder (heart diseases)
  10. Cerebral haemorrhage (bleeding within the brain)

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 39.39%
  2. Migraine (headache): 11 people, 33.33%
  3. Menopause (end of monthly cycles in women): 11 people, 33.33%
  4. Cardiac Disorder: 11 people, 33.33%
  5. Pain: 10 people, 30.30%
  6. Hypersensitivity: 10 people, 30.30%
  7. Menopausal Symptoms: 6 people, 18.18%
  8. Osteoporosis (bones weak and more likely to break): 3 people, 9.09%
  9. Hot Flush (sudden feelings of heat): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Vagifem and Ogen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vagifem and Ogen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vagifem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ogen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vagifem and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ogen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on estradiol and estropipate (the active ingredients of Vagifem and Ogen, respectively), and Vagifem and Ogen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.