Valproate sodium and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproate sodium (valproate sodium) and Oxycodone (oxycodone hydrochloride). Common drug interactions include congestive cardiomyopathy among females and dysphagia among males.

The phase IV clinical study analyzes what interactions people have when they take Valproate sodium and Oxycodone. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

On Jul, 13, 2026

68 people who take Valproate sodium and Oxycodone together, and have interactions are studied.

Valproate sodium and Oxycodone drug interactions.

What are the common drug interactions of Valproate Sodium and Oxycodone, by gender? *:

female:

Congestive cardiomyopathy (weakening of heart muscle)
Electrocardiogram qt prolonged
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Personality disorder
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Ejection fraction decreased (systolic heart failure)
Folate deficiency (lack of folic acid)
Hypoxia (low oxygen in tissues)
Thrombocytopenia (decrease of platelets in blood)
Blood pressure decreased

male:

Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Sepsis (a severe blood infection that can lead to organ failure and death)
Tardive dyskinesia (a disorder that involves involuntary movements)
Asthenia (weakness)
Skin ulcer
Disability
Cachexia (loss of weight)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Feeding disorder (when children refuse to eat certain food groups)

What are the common drug interactions of Valproate Sodium and Oxycodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal distension
Abdominal pain
Abscess jaw (tooth abscess or root abscess)
Acidosis hyperchloraemic (increased acidity in the blood and other body tissue with decrease in plasma bicarbonate concentration)
Actinic keratosis (skin disease due to sun exposure)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Acute myocardial infarction (acute heart attack)
Agitation (state of anxiety or nervous excitement)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

20-29:

Completed suicide (act of taking one's own life)
Drowning (process of experiencing respiratory impairment from submersion/immersion in liquid)
Intentional self-injury
Overdose
Sedation
Anxiety
Blood pressure decreased
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Depression
Heart rate increased

30-39:

Chest pain
Congestive cardiomyopathy (weakening of heart muscle)
Depression
Ejection fraction decreased (systolic heart failure)
Electrocardiogram qt prolonged
Intentional self-injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Personality disorder
Suicide attempt
Aggression

40-49:

Iron deficiency
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Skin ulcer
Chest discomfort
Skin burning sensation
Burning sensation
Chest pain
Confusional state

50-59:

Platelet count increased
Presyncope
Restlessness (not able to rest)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stent occlusion (blockage of stent)
Stent related infection (infection due to stent)
Syncope (loss of consciousness with an inability to maintain postural tone)
Weight decreased
Wound
Vomiting

60+:

Aptyalism (deficiency or absence of saliva)
Delirium (wild excitement)
Tardive dyskinesia (a disorder that involves involuntary movements)
Thrombocytopenia (decrease of platelets in blood)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Feeding disorder (when children refuse to eat certain food groups)
Mobility decreased (ability to move is reduced)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 7 people, 10.29%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 7.35%
Stress And Anxiety: 4 people, 5.88%
Insomnia (sleeplessness): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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