Vascepa and Plaquenil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vascepa (icosapent ethyl) and Plaquenil (hydroxychloroquine sulfate). Common drug interactions include allergy to chemicals among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Vascepa and Plaquenil. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Vascepa?

Vascepa has active ingredients of icosapent ethyl. It is often used in high blood cholesterol. eHealthMe is studying from 5,894 Vascepa users. Check the latest studies of Vascepa.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

On Jul, 11, 2026

24 people who take Vascepa and Plaquenil together, and have interactions are studied.

Vascepa and Plaquenil drug interactions.

What are the common drug interactions of Vascepa and Plaquenil, by gender? *:

female:

Allergy to chemicals
Dehydration (dryness resulting from the removal of water)
Dizziness
Flushing (the warm, red condition of human skin)
Gastrointestinal infection (infection of stomach and intestine)
Hypokalaemia (low potassium)
Irritable bowel syndrome
Memory impairment
Migraine (headache)
Myalgia (muscle pain)

male:

Anxiety
Arthropathy
Bone erosion
Cartilage injury
Exostosis (formation of new bone on the surface of a bone)
Joint dislocation (a joint position is changed from normal position)
Joint swelling
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Procedural pain

What are the common drug interactions of Vascepa and Plaquenil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Blood sodium decreased
Chest pain
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Injection site erythema (redness at injection site)
Injection site mass
Injection site pain
Low density lipoprotein
Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

Allergy to chemicals
Dehydration (dryness resulting from the removal of water)
Dizziness
Flushing (the warm, red condition of human skin)
Hypokalaemia (low potassium)
Irritable bowel syndrome
Memory impairment
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Pain in jaw

50-59:

Gastrointestinal infection (infection of stomach and intestine)
Urinary tract infection
Abdominal discomfort
Blood pressure increased
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Fall
Headache (pain in head)
Pain
Patella fracture
Sinusitis (inflammation of sinus)

60+:

Arthralgia (joint pain)
Back pain
Sciatic nerve neuropathy (sciatic nerve damage)
Death
Endotracheal intubation complication
Drug hypersensitivity
Dysphonia (speech disorder attributable to a disorder of phonation)
Fibromyalgia (a long-term condition which causes pain all over the body)
Hallucination (an experience involving the perception of something not present)
Intervertebral disc injury (spinal disc injury)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 16.67%
Immunodeficiency Common Variable: 4 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 16.67%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 12.50%
Nausea (feeling of having an urge to vomit): 3 people, 12.50%
High Blood Pressure: 3 people, 12.50%
Cardiac Failure Congestive: 3 people, 12.50%
Asthma: 3 people, 12.50%
Nausea And Vomiting: 2 people, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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