Vesanoid and Diflucan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vesanoid (tretinoin) and Diflucan (fluconazole). Common drug interactions include blood bilirubin increased among females and disseminated intravascular coagulation among males.

The phase IV clinical study analyzes what interactions people have when they take Vesanoid and Diflucan. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Vesanoid?

Vesanoid has active ingredients of tretinoin. eHealthMe is studying from 1,366 Vesanoid users. Check the latest studies of Vesanoid.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

On Jul, 10, 2026

84 people who take Vesanoid and Diflucan together, and have interactions are studied.

Vesanoid and Diflucan drug interactions.

What are the common drug interactions of Vesanoid and Diflucan, by gender? *:

female:

Blood bilirubin increased
Disseminated intravascular coagulation (systemic activation of blood coagulation)
White blood cell count decreased
Blood chloride decreased
Blood urea decreased
Bone disorder
Platelet count decreased
Pleural effusion (water on the lungs)
Premature baby
Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)

male:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Vomiting
Haemoglobin decreased
Hypervitaminosis a (state of vitamin a toxicity)
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Neutropenia (an abnormally low number of neutrophils)
Platelet count decreased
Pulmonary alveolar haemorrhage (acute bleeding)

What are the common drug interactions of Vesanoid and Diflucan, by age (0-1 to 60+)? *:

0-1:

Bone disorder
Premature baby
Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)
Thrombocytosis
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Apgar score low
Maternal exposure during pregnancy (use of substance during pregnancy)

2-9:

n/a

10-19:

Histiocytosis haematophagic
Creatinine renal clearance decreased
Cystitis haemorrhagic (blood in the urine and painful voiding)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Oliguria (not enough urine)
Platelet count decreased
Red blood cell count decreased
Renal failure (kidney dysfunction)
White blood cell count decreased

20-29:

Dry skin
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Scrotal ulcer
Abdominal distension
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Blood creatinine increased
Constipation
Dehydration (dryness resulting from the removal of water)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Headache (pain in head)

30-39:

Placental insufficiency
Arthralgia (joint pain)
Joint swelling
Maternal exposure during delivery (use of substance during pregnancy)
Premature delivery

40-49:

Blood lactate dehydrogenase increased
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Sepsis (a severe blood infection that can lead to organ failure and death)
Activated partial thromboplastin time prolonged
Erythema multiforme (a type of hypersensitivity reaction)
Lip dry
Vomiting
Blood alkaline phosphatase nos increased

50-59:

Respiratory disorder (respiratory disease)
Speech disorder
Thrombocytopenia (decrease of platelets in blood)
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Alanine aminotransferase increased
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Aspartate aminotransferase increased
Blepharitis (chronic inflammation of the eyelid)
Blood albumin increased
Blood chloride decreased

60+:

Hypervitaminosis a (state of vitamin a toxicity)
Renal failure acute (rapid kidney dysfunction)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Fibrin degradation products increased
Granuloma (a small area of inflammation due to tissue injury)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperkalaemia (damage to or disease of the kidney)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lip dry
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Acute Promyelocytic Leukaemia (cancer of the blood and bone marrow): 20 people, 23.81%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 7.14%
Maternal Therapy To Enhance Foetal Lung Maturity: 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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