Vibramycin and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vibramycin (doxycycline) and Spironolactone (spironolactone). Common drug interactions include bradycardia among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Vibramycin and Spironolactone. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Vibramycin?

Vibramycin has active ingredients of doxycycline. It is often used in acne. eHealthMe is studying from 1,692 Vibramycin users. Check the latest studies of Vibramycin.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

On Jul, 11, 2026

22 people who take Vibramycin and Spironolactone together, and have interactions are studied.

Vibramycin and Spironolactone drug interactions.

What are the common drug interactions of Vibramycin and Spironolactone, by gender? *:

female:

Bradycardia (abnormally slow heart action)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Sinusitis (inflammation of sinus)
Abdominal pain
Acute myocardial infarction (acute heart attack)
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Anaemia (lack of blood)
Anxiety
Aortic thrombosis (formation of a blood clot inside aorta)
Aortic valve incompetence

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coagulopathy (blood's ability to clot is impaired)
Fatigue (feeling of tiredness)
Malignant neoplasm progression (cancer tumour came back)
Petechiae (a small red or purple spot caused by bleeding into the skin)

What are the common drug interactions of Vibramycin and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

50-59:

Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Renal failure (kidney dysfunction)
Joint injury

60+:

Acute myocardial infarction (acute heart attack)
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Bradycardia (abnormally slow heart action)
Carotid artery stenosis (narrowing of carotid artery)
Cellulitis (infection under the skin)
Chest pain
Dehydration (dryness resulting from the removal of water)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dysphonia (speech disorder attributable to a disorder of phonation)
Failure to thrive (inadequate weight gain and physical growth in children)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 31.82%
Stress And Anxiety: 5 people, 22.73%
Rhinorrhea (watery mucus discharge from the nose): 5 people, 22.73%
Quit Smoking: 5 people, 22.73%
Inflammation: 5 people, 22.73%
Infection: 5 people, 22.73%
Fluid Retention (an abnormal accumulation of fluid in the blood): 5 people, 22.73%
Diabetes: 5 people, 22.73%
Depression: 5 people, 22.73%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 5 people, 22.73%

* Approximation only. Some reports may have incomplete information.

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