Vitamin e and Evoxac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vitamin e (tocopherols and tocotrienols) and Evoxac (cevimeline hydrochloride). Common drug interactions include hypertonic bladder among females and blood creatine phosphokinase mb increased among males.

The phase IV clinical study analyzes what interactions people have when they take Vitamin e and Evoxac. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

What is Evoxac?

Evoxac has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 2,028 Evoxac users. Check the latest studies of Evoxac.

On Jul, 15, 2026

36 people who take Vitamin e and Evoxac together, and have interactions are studied.

What are the common drug interactions of Vitamin E and Evoxac, by gender? *:

female:

Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Ilium fracture
Incontinence (lack of moderation or self-control)
Infection
Fall
Arthralgia (joint pain)
Diarrhoea
Drug ineffective
Fibromyalgia (a long-term condition which causes pain all over the body)

male:

Blood creatine phosphokinase mb increased
Bone disorder
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Sweating increased (excess sweating)
Burning sensation
Cardiac enzymes increased
Chest pain
Decreased activity
Dizziness (excl vertigo)

What are the common drug interactions of Vitamin E and Evoxac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Breakthrough pain
Hyperhidrosis (abnormally increased sweating)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Therapeutic response unexpected

40-49:

n/a

50-59:

Flushing (the warm, red condition of human skin)
Headache (pain in head)
Irritable bowel syndrome
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Tenderness (pain or discomfort when an affected area is touched)
Abdominal discomfort
Abdominal pain
Abdominal pain upper

60+:

Fall
Nausea (feeling of having an urge to vomit)
Anxiety
Back pain
Bursa disorder
Depression
Drug ineffective
Fibromyalgia (a long-term condition which causes pain all over the body)
Headache (pain in head)
Inflammation

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 22.22%
Insomnia (sleeplessness): 6 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 13.89%
Pain: 4 people, 11.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 11.11%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 8.33%
Osteoporosis (bones weak and more likely to break): 3 people, 8.33%
Stress And Anxiety: 2 people, 5.56%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 5.56%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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