Vytorin and Eplerenone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vytorin (ezetimibe; simvastatin) and Eplerenone (eplerenone). Common drug interactions include cardiac failure among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Vytorin and Eplerenone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

What is Eplerenone?

Eplerenone has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 9,979 Eplerenone users. Check the latest studies of Eplerenone.

On Jul, 28, 2026

20 people who take Vytorin and Eplerenone together, and have interactions are studied.

Vytorin and Eplerenone drug interactions.

What are the common drug interactions of Vytorin and Eplerenone, by gender? *:

female:

Cardiac failure
Upper respiratory tract infection
Vertigo
Anxiety
Cerebral thrombosis (blood clot in brain)
Death
Emotional distress
Fear
Multi-organ failure (multisystem organ failure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disease progression
Dizziness
Fear
Gastric disorder (disease of stomach)
Hypokalaemia (low potassium)

What are the common drug interactions of Vytorin and Eplerenone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

40-49:

n/a

50-59:

Cardiac failure
Upper respiratory tract infection
Vertigo
Anxiety
Cerebral thrombosis (blood clot in brain)
Death
Emotional distress
Fear
Multi-organ failure (multisystem organ failure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

Hypotension (abnormally low blood pressure)
Multi-organ failure (multisystem organ failure)
Fear
Gastric disorder (disease of stomach)
Hypokalaemia (low potassium)
Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Pain
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Cardiac Failure: 5 people, 25.00%
Gout (uric acid crystals building up in the body): 2 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.00%
Cardiac Failure Congestive: 2 people, 10.00%
Dyspnea (difficult or laboured breathing): 2 people, 10.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 10.00%
Abdominal Pain Upper: 2 people, 10.00%
Pain: 2 people, 10.00%
Renal Cell Carcinoma (a kidney cancer): 2 people, 10.00%
Sleep Disorder: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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