Vyvanse and Glimepiride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Glimepiride (glimepiride). Common drug interactions include nasopharyngitis among females and arthropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Glimepiride. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,872 Vyvanse users. Check the latest studies of Vyvanse.

What is Glimepiride?

Glimepiride has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 45,910 Glimepiride users. Check the latest studies of Glimepiride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

23 people who take Vyvanse and Glimepiride together, and have interactions are studied.

Vyvanse and Glimepiride drug interactions.

What are the common drug interactions of Vyvanse and Glimepiride, by gender? *:

female:

Nasopharyngitis (inflammation of the nasopharynx)
Abdominal distension
Influenza
Rash
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Neuropathy peripheral (surface nerve damage)
Peripheral coldness
Rash pruritic (redness with itching)
Sinusitis (inflammation of sinus)
Therapeutic response unexpected

male:

Arthropathy
Concussion (short loss of normal brain function in response to a head injury)
Nausea (feeling of having an urge to vomit)
Neck pain
Pain
Photosensitivity reaction
Renal failure (kidney dysfunction)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anger
Anxiety

What are the common drug interactions of Vyvanse and Glimepiride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Rash
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Sleep disorder
Pruritus (severe itching of the skin)
Scab (a hard coating on the skin formed during the wound healing)
Skin swelling
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

40-49:

Anger
Anxiety
Blood glucose increased
Chronic kidney disease

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Influenza
Nasopharyngitis (inflammation of the nasopharynx)
Neuropathy peripheral (surface nerve damage)
Peripheral coldness
Rash pruritic (redness with itching)
Sinusitis (inflammation of sinus)
Therapeutic response unexpected
Vision blurred
Abdominal distension

60+:

Abdominal distension
Dyspnoea (difficult or laboured respiration)
Blood potassium decreased
Face oedema (swelling of face)
Headache (pain in head)
Hypertension (high blood pressure)
Infusion related reaction
Oedema peripheral (superficial swelling)
Pneumonia
Vomiting

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 26.09%
High Blood Cholesterol: 5 people, 21.74%
Immunodeficiency Common Variable: 4 people, 17.39%
Depression: 4 people, 17.39%
High Blood Pressure: 3 people, 13.04%
Pain: 2 people, 8.70%
Neck Pain: 2 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.70%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 8.70%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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