Benadryl and Dyshidrotic eczema - a phase IV clinical study of FDA data

Summary:

Dyshidrotic eczema is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 50-59 old, also take Methotrexate, and have Neoplasm malignant.

The phase IV clinical study analyzes which people have Dyshidrotic eczema when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,956 Benadryl users. Check the latest studies of Benadryl.

What is Dyshidrotic eczema?

Dyshidrotic eczema (skin condition in which blisters develop on the soles of your feet and/or the palms of hands) is found to be associated with 123 drugs and 320 conditions by eHealthMe. Check the latest studies of Dyshidrotic eczema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 21 people (0.02%) have Dyshidrotic eczema.

Could Benadryl cause Dyshidrotic eczema?

Among these 21 people:

What is the gender of people who have Dyshidrotic eczema when taking Benadryl? *

female: 94.74 %
male: 5.26 %

What is the age of people who have Dyshidrotic eczema when taking Benadryl? *

What are other drugs people take besides Benadryl? *

Methotrexate: 15 people, 71.43%
Zyrtec: 11 people, 52.38%
Cytoxan: 11 people, 52.38%
Hydroxyzine: 11 people, 52.38%
Zometa: 11 people, 52.38%
Naprosyn: 11 people, 52.38%
Gemzar: 11 people, 52.38%
Neurontin: 11 people, 52.38%
Nizoral: 11 people, 52.38%
Prochlorperazine Maleate: 11 people, 52.38%

What are other side effects people have besides Dyshidrotic eczema? *

Pain In Extremity: 15 people, 71.43%
Joint Pain: 15 people, 71.43%
Depression: 14 people, 66.67%
Urticaria (rash of round, red welts on the skin that itch intensely): 14 people, 66.67%
Eye Swelling: 13 people, 61.90%
Cellulitis (infection under the skin): 13 people, 61.90%
Fibromyalgia (a long-term condition which causes pain all over the body): 12 people, 57.14%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 12 people, 57.14%
Essential Hypertension (primary hypertension): 11 people, 52.38%
Duodenogastric Reflux (bile flows upward from the small intestine into the stomach): 11 people, 52.38%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 7 people, 33.33%
Neoplasm Malignant (cancer tumour): 7 people, 33.33%
Sle Arthritis (an autoimmune disease that causes your immune system to attack your body's own joints): 4 people, 19.05%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 3 people, 14.29%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 9.52%
Ovarian Cancer (cancer of ovary): 2 people, 9.52%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 9.52%
Asthma: 2 people, 9.52%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Dyshidrotic eczema?

- Check whether Dyshidrotic eczema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,956 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dyshidrotic eczema:

Dyshidrotic eczema (123 drugs)

Browse all the conditions that are associated with Dyshidrotic eczema:

Dyshidrotic eczema (320 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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