Wellbutrin and Amphetamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wellbutrin (bupropion hydrochloride) and Amphetamine (amphetamine). Common drug interactions include erythema among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Wellbutrin and Amphetamine. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,110 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Amphetamine?

Amphetamine has active ingredients of amphetamine. eHealthMe is studying from 980 Amphetamine users. Check the latest studies of Amphetamine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

11 people who take Wellbutrin and Amphetamine together, and have interactions are studied.

Wellbutrin and Amphetamine drug interactions.

What are the common drug interactions of Wellbutrin and Amphetamine, by gender? *:

female:

Erythema (redness of the skin)
Fungal rhinitis (infection of the mucous membrane inside the nose due to fungus)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Infection
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Plantar fasciitis (painful inflammatory process of the plantar fascia)
Pruritus (severe itching of the skin)
Sinusitis (inflammation of sinus)
Staphylococcal infection (an infection with staphylococcus bacteria)

male:

Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Chronic kidney disease
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Wellbutrin and Amphetamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)

40-49:

n/a

50-59:

Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Atrioventricular block first degree (heart block first degree)
Blood creatine phosphokinase increased
Blood creatinine increased
Bradycardia (abnormally slow heart action)
Conduction disorder (serious disorder of the heart not responses proper to impulses)
Confusional state
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Delirium (wild excitement)

60+:

n/a

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 36.36%
Immunodeficiency Common Variable: 3 people, 27.27%
Prostatic Disorder: 2 people, 18.18%
Diabetes: 2 people, 18.18%
Cardiac Disorder: 2 people, 18.18%
Indigestion: 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
High Blood Cholesterol: 2 people, 18.18%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 9.09%
Birth Control: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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