Wellbutrin and Feldene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wellbutrin (bupropion hydrochloride) and Feldene (piroxicam). Common drug interactions include drug hypersensitivity among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Wellbutrin and Feldene. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Feldene?

Feldene has active ingredients of piroxicam. It is often used in arthritis. eHealthMe is studying from 3,913 Feldene users. Check the latest studies of Feldene.



On Jul, 11, 2026

44 people who take Wellbutrin and Feldene together, and have interactions are studied.

Wellbutrin and Feldene drug interactions.

What are the common drug interactions of Wellbutrin and Feldene, by gender? *:

female:

  1. Drug hypersensitivity
  2. Drug ineffective
  3. Memory impairment
  4. Anger
  5. Cardiac failure congestive
  6. Dyspepsia (indigestion)
  7. Dyspnoea (difficult or laboured respiration)
  8. Ejection fraction decreased (systolic heart failure)
  9. Headache (pain in head)
  10. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

male:

  1. Back pain
  2. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  3. Abscess (pus)
  4. Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
  5. Arrhythmia (irregular heartbeat)
  6. Arthralgia (joint pain)
  7. Bladder cancer
  8. Bladder mass
  9. Cardiomegaly (increased size of heart than normal)
  10. Cardiomyopathy (weakening of the heart muscle)

What are the common drug interactions of Wellbutrin and Feldene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Convulsive threshold lowered
  2. Decreased appetite
  3. Dry eye (lack of adequate tears)
  4. Dry mouth

20-29:

  1. Abdominal pain upper
  2. Abscess (pus)
  3. Alcoholic liver disease
  4. Anaemia (lack of blood)
  5. Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
  6. Arrhythmia (irregular heartbeat)
  7. Arterial stenosis (abnormal narrowing of the aortic valve in the heart)
  8. Arthralgia (joint pain)
  9. Arthropathy
  10. Atelectasis (partial or complete collapse of the lung)

30-39:

n/a

40-49:

  1. Flatulence (flatus expelled through the anus)
  2. Chronic kidney disease

50-59:

  1. Chemotherapy
  2. Contusion (a type of hematoma of tissue in which capillaries)
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  4. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  5. Cough
  6. Dehydration (dryness resulting from the removal of water)
  7. Delusion (a false belief or opinion)
  8. Dyskinesia (abnormality or impairment of voluntary movement)
  9. Dyspepsia (indigestion)
  10. Dyspnoea (difficult or laboured respiration)

60+:

  1. Fall
  2. Back pain
  3. Dysphagia (a condition in which swallowing is difficult or painful)
  4. Herpes zoster
  5. Intention tremor (brain tremor)
  6. Lymphoedema (localized fluid retention and tissue swelling)
  7. Memory impairment
  8. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  9. Osteoporosis (bones weak and more likely to break)
  10. Pain

What are the existing conditions these people have? *

  1. Bone Disorder: 15 people, 34.09%
  2. Multiple Myeloma (cancer of the plasma cells): 10 people, 22.73%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.09%
  4. Stress And Anxiety: 3 people, 6.82%
  5. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.82%
  6. Pain: 3 people, 6.82%
  7. Insomnia (sleeplessness): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Wellbutrin and Feldene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Wellbutrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Feldene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Wellbutrin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Feldene and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride and piroxicam (the active ingredients of Wellbutrin and Feldene, respectively), and Wellbutrin and Feldene (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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