Wellbutrin and Pentoxifylline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wellbutrin (bupropion hydrochloride) and Pentoxifylline (pentoxifylline). Common drug interactions include pneumonia among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Wellbutrin and Pentoxifylline. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Pentoxifylline?

Pentoxifylline has active ingredients of pentoxifylline. eHealthMe is studying from 5,997 Pentoxifylline users. Check the latest studies of Pentoxifylline.

On Jul, 10, 2026

32 people who take Wellbutrin and Pentoxifylline together, and have interactions are studied.

Wellbutrin and Pentoxifylline drug interactions.

What are the common drug interactions of Wellbutrin and Pentoxifylline, by gender? *:

female:

Pneumonia
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tooth deposit
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Tremor (trembling or shaking movements in one or more parts of your body)
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls)
Sinusitis (inflammation of sinus)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chest pain

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Alcohol poisoning
Alcohol withdrawal syndrome
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Brain compression
Brain contusion (a form of traumatic brain injury)
Brain injury
Brain midline shift
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

What are the common drug interactions of Wellbutrin and Pentoxifylline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug screen false positive
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Renal failure acute (rapid kidney dysfunction)

30-39:

Chest pain
Fatigue (feeling of tiredness)
Headache (pain in head)
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Renal failure (kidney dysfunction)
Agitation (state of anxiety or nervous excitement)
Alcohol poisoning
Alcohol withdrawal syndrome
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Brain compression
Brain contusion (a form of traumatic brain injury)
Brain injury
Brain midline shift
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

50-59:

Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic kidney disease
Drug ineffective
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Abdominal distension
Asthenia (weakness)
Chills (felling of cold)
Constipation
Decreased appetite

60+:

Sinusitis (inflammation of sinus)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cataract (clouding of the lens inside the eye)
Cerebral atrophy (decrement in size of brain)
Cholecystitis (infection of gallbladder)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colitis pseudomembranous (antibiotic-associated diarrhoea)
Disease progression
Drug toxicity
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Pain: 12 people, 37.50%
Bipolar Disorder (mood disorder): 5 people, 15.62%
Stress And Anxiety: 5 people, 15.62%
Constipation: 5 people, 15.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 15.62%
Heart Disease: 5 people, 15.62%
High Blood Cholesterol: 5 people, 15.62%
High Blood Pressure: 5 people, 15.62%
Urinary Tract Infection: 4 people, 12.50%
Bladder Disorder: 4 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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