Xarelto and Emgality drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xarelto (rivaroxaban) and Emgality (galcanezumab-gnlm). Common drug interactions include postural orthostatic tachycardia syndrome among females and chest discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Xarelto and Emgality. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Xarelto?

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 212,378 Xarelto users. Check the latest studies of Xarelto.

What is Emgality?

Emgality has active ingredients of galcanezumab-gnlm. eHealthMe is studying from 24,702 Emgality users. Check the latest studies of Emgality.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

24 people who take Xarelto and Emgality together, and have interactions are studied.

What are the common drug interactions of Xarelto and Emgality, by gender? *:

female:

Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Erythema (redness of the skin)
Malaise (a feeling of general discomfort or uneasiness)
Weight decreased
Skin reaction
Asthma
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Stiff person syndrome
Hypoxia (low oxygen in tissues)
Impaired gastric emptying

male:

Chest discomfort
Confusional state
Head discomfort
Headache (pain in head)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Injection site pain
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

What are the common drug interactions of Xarelto and Emgality, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Back pain
Blood glucose increased
Decreased appetite
Device expulsion
Fatigue (feeling of tiredness)
Menstruation irregular
Mood swings (an extreme or rapid change in mood)
Nausea (feeling of having an urge to vomit)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)

40-49:

Asthma
Dyspnoea (difficult or laboured respiration)
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Erythema (redness of the skin)
Impaired gastric emptying
Malaise (a feeling of general discomfort or uneasiness)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Fall
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Nephrolithiasis (calculi in the kidneys)
Pyrexia (fever)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Stress
Urinary tract infection
Dyspnoea (difficult or laboured respiration)
Gastroenteritis (inflammation of stomach and intestine)

60+:

Chest discomfort
Headache (pain in head)
Heart rate increased

What are the existing conditions these people have? *

Immune System Disorder: 8 people, 33.33%
Migraine (headache): 5 people, 20.83%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 12.50%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 8.33%
High Blood Pressure: 2 people, 8.33%
Diabetes: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Xarelto and Emgality?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously