Xyrem and Androderm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyrem (sodium oxybate) and Androderm (testosterone). Common drug interactions include gait disturbance among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Xyrem and Androderm. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is Androderm?

Androderm has active ingredients of testosterone. It is often used in testosterone. eHealthMe is studying from 4,115 Androderm users. Check the latest studies of Androderm.

On Jul, 28, 2026

30 people who take Xyrem and Androderm together, and have interactions are studied.

What are the common drug interactions of Xyrem and Androderm, by gender? *:

female:

Gait disturbance

male:

Weight decreased
Constipation
Cyclic vomiting syndrome (prolonged episodes of severe nausea, vomiting)
Depression
Dyskinesia (abnormality or impairment of voluntary movement)
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries))
Hyposmia (impairment of the sense of smell)
Increased appetite
Joint injury
Nephrolithiasis (calculi in the kidneys)

What are the common drug interactions of Xyrem and Androderm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Back pain
Cat scratch disease (bacterial infection by cat scratch)
Coma (state of unconsciousness lasting more than six hours)
Constipation
Cyclic vomiting syndrome (prolonged episodes of severe nausea, vomiting)
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Hyposmia (impairment of the sense of smell)
Impaired gastric emptying
Increased appetite

30-39:

n/a

40-49:

Herpes zoster
Osteoporosis (bones weak and more likely to break)
Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Weight decreased
Eye injury

50-59:

Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Micturition urgency (urgency to pass the urine)
Weight decreased

60+:

Loss of consciousness

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 66.67%
Drowsiness: 6 people, 20.00%
Sleep Disorder: 3 people, 10.00%
Seborrheic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 3 people, 10.00%
Hypersensitivity: 3 people, 10.00%
High Blood Pressure: 3 people, 10.00%
High Blood Cholesterol: 3 people, 10.00%
Depression: 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Xyrem and Androderm?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously