Xyrem and Decadron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyrem (sodium oxybate) and Decadron (dexamethasone). Common drug interactions include ankle fracture among females and adjustment disorder with depressed mood among males.

The phase IV clinical study analyzes what interactions people have when they take Xyrem and Decadron. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is Decadron?

Decadron has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 47,210 Decadron users. Check the latest studies of Decadron.

On Jul, 20, 2026

24 people who take Xyrem and Decadron together, and have interactions are studied.

What are the common drug interactions of Xyrem and Decadron, by gender? *:

female:

Ankle fracture
Anxiety
Peripheral swelling
Constipation
Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate increased
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Nervousness
Pancreatitis chronic (chronic inflammation of pancreas)

male:

Adjustment disorder with depressed mood
Colonoscopy
Breast cancer
Acne (skin problems that cause pimples)
Arthropathy
Bacterial infection
Blood glucose increased
Cluster headache (one-sided head pain with tearing)
Cyst (a closed sac)
Erythema (redness of the skin)

What are the common drug interactions of Xyrem and Decadron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Breast cancer
Cyst (a closed sac)
Erythema (redness of the skin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lymph node calcification (calcium deposit in lymph node)
Mass
Night sweats (sweating in night)
Scar
Spleen disorder (disease of spleen)
Weight decreased

50-59:

Ankle fracture
Peripheral swelling
Rash erythematous (redness of the skin)
Therapeutic response unexpected
Tremor (trembling or shaking movements in one or more parts of your body)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Surgery
Adjustment disorder with depressed mood
Colonoscopy
Cough

60+:

n/a

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 41.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 16.67%
Heart Rate Increased: 4 people, 16.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 16.67%
Drowsiness: 4 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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