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Xyrem and Erythrocin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyrem (sodium oxybate) and Erythrocin (erythromycin lactobionate). Common drug interactions include nausea among females and knee arthroplasty among males.

The phase IV clinical study analyzes what interactions people have when they take Xyrem and Erythrocin. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is Erythrocin?

Erythrocin has active ingredients of erythromycin lactobionate. It is often used in tooth abscess. eHealthMe is studying from 1,200 Erythrocin users. Check the latest studies of Erythrocin.

On Jul, 10, 2026

15 people who take Xyrem and Erythrocin together, and have interactions are studied.

Xyrem and Erythrocin drug interactions.

What are the common drug interactions of Xyrem and Erythrocin, by gender? *:

female:

  1. Nausea (feeling of having an urge to vomit)
  2. Vitamin d deficiency
  3. Acne (skin problems that cause pimples)
  4. Eating disorder
  5. Vomiting
  6. Psychiatric symptom
  7. Bladder disorder
  8. Drug diversion
  9. Drug effect decreased
  10. Hysterectomy

male:

  1. Knee arthroplasty
  2. Psoriasis (immune-mediated disease that affects the skin)
  3. Ulcerative keratitis (ulcerative inflammation of the cornea)

What are the common drug interactions of Xyrem and Erythrocin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Psoriasis (immune-mediated disease that affects the skin)
  2. Ulcerative keratitis (ulcerative inflammation of the cornea)

50-59:

  1. Knee arthroplasty

60+:

n/a

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 53.33%
  2. Nausea (feeling of having an urge to vomit): 1 person, 6.67%
  3. Drowsiness: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Xyrem and Erythrocin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Xyrem and Erythrocin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xyrem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Erythrocin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xyrem and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Erythrocin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on sodium oxybate and erythromycin lactobionate (the active ingredients of Xyrem and Erythrocin, respectively), and Xyrem and Erythrocin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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