Yaz and Lomotil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Yaz (drospirenone; ethinyl estradiol) and Lomotil (atropine sulfate; diphenoxylate hydrochloride). Common drug interactions include gallbladder operation among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Yaz and Lomotil. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

On Jul, 12, 2026

50 people who take Yaz and Lomotil together, and have interactions are studied.

What are the common drug interactions of Yaz and Lomotil, by gender? *:

female:

Gallbladder operation
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Iliac vein occlusion (narrowing of an iliac vein segment between the aortic bifurcation and the groin)
Leukoencephalopathy (disease of the white matter in the brain)
Pelvic pain
Pregnancy on oral contraceptive
Rib fracture
Salmonellosis (an infection with salmonella bacteria)
Spinal compression fracture (fracture due to spinal compression on bone)
Spinal cord compression

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Drug ineffective
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Peripheral swelling
Pregnancy with contraceptive device
Abdominal pain
Cholecystitis (infection of gallbladder)
Emotional distress

What are the common drug interactions of Yaz and Lomotil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Depression
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cellulitis (infection under the skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pain in extremity
Pyrexia (fever)
Cholecystitis (infection of gallbladder)
Local swelling (swelling at the site of some application of substance or injury)

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Pain
Nephrolithiasis (calculi in the kidneys)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Injury
Anxiety
Emotional distress
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastric disorder (disease of stomach)

30-39:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Unintended pregnancy (unwanted pregnancies as well as those that are mistimed)
Pain
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Emotional distress
Gallbladder disorder
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal pain upper

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gait disturbance
Oedema peripheral (superficial swelling)
Pain in extremity
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Injury
Nausea (feeling of having an urge to vomit)
Thrombotic stroke (stroke due to clot formation)
Vertigo
Vomiting

50-59:

Bone pain
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Migraine (headache)
Mitral valve incompetence (inefficient heart valve)
Oedema peripheral (superficial swelling)
Pleural effusion (water on the lungs)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Thyroid cancer metastatic (thyroid cancer spreads to other part)

60+:

Emotional distress
Abdominal pain
Pelvic venous thrombosis (blood clot occurring inside a blood vessel and thromboses (dvts) that form in the deep veins of the legs or in the pelvic veins)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Vena cava thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart)
Vomiting
Acute respiratory distress syndrome
Anxiety
Cholecystitis (infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 9 people, 18.00%
Premenstrual Syndrome: 8 people, 16.00%
Nausea (feeling of having an urge to vomit): 7 people, 14.00%
Headache (pain in head): 7 people, 14.00%
Stress And Anxiety: 6 people, 12.00%
Thyroid Diseases: 5 people, 10.00%
Menstruation Irregular: 5 people, 10.00%
Multiple Allergies (allergy to multiple agents): 4 people, 8.00%
Migraine (headache): 4 people, 8.00%
Indigestion: 4 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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