Zebeta and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zebeta (bisoprolol fumarate) and Methotrexate (methotrexate sodium). Common drug interactions include weight increased among females and acute coronary syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Zebeta and Methotrexate. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Zebeta?

Zebeta has active ingredients of bisoprolol fumarate. It is often used in high blood pressure. eHealthMe is studying from 1,734 Zebeta users. Check the latest studies of Zebeta.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

On Aug, 07, 2026

49 people who take Zebeta and Methotrexate together, and have interactions are studied.

Zebeta and Methotrexate drug interactions.

What are the common drug interactions of Zebeta and Methotrexate, by gender? *:

female:

Weight increased
Arthralgia (joint pain)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Behcet's syndrome (involves inflammation of the blood vessels)
Dyspnoea (difficult or laboured respiration)
Depression
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Drug ineffective
Nausea (feeling of having an urge to vomit)
Pneumonia

male:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blindness
Coagulopathy (blood's ability to clot is impaired)
Dyspnoea (difficult or laboured respiration)
Embolic stroke (stroke due to obstruction due to an embolus)
Fatigue (feeling of tiredness)
International normalised ratio increased
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)

What are the common drug interactions of Zebeta and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Behcet's syndrome (involves inflammation of the blood vessels)
Depression
Incoherent (talking in a confused and unclear way)
Weight increased

40-49:

Antinuclear antibody positive
Arthralgia (joint pain)
Dry skin
Fibromyalgia (a long-term condition which causes pain all over the body)
Hypoaesthesia (reduced sense of touch or sensation)
Limb discomfort (discomfort in leg)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Overdose

50-59:

Muscle cramp (painful sensation caused by muscle contraction)
Neoplasm malignant (cancer tumour)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Ovarian cancer (cancer of ovary)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Pulmonary mass
Sinusitis (inflammation of sinus)
Vision blurred
Pneumonia
Hepatic failure (liver failure)

60+:

Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Mouth ulceration (mouth ulcers)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Rash
Red blood cell sedimentation rate increased
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the existing conditions these people have? *

Inflammation: 7 people, 14.29%
Stress And Anxiety: 6 people, 12.24%
High Blood Cholesterol: 6 people, 12.24%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 10.20%
Migraine (headache): 5 people, 10.20%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 10.20%
Hormone Level Abnormal: 5 people, 10.20%
Skin Disorder (skin disease): 5 people, 10.20%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 10.20%
Behcet's Syndrome (involves inflammation of the blood vessels): 5 people, 10.20%

* Approximation only. Some reports may have incomplete information.

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