Zide and Irinotecan hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Irinotecan hydrochloride (irinotecan hydrochloride). Common drug interactions include febrile neutropenia among females and neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Irinotecan hydrochloride. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Irinotecan hydrochloride?

Irinotecan hydrochloride has active ingredients of irinotecan hydrochloride. It is often used in cancer. eHealthMe is studying from 7,166 Irinotecan hydrochloride users. Check the latest studies of Irinotecan hydrochloride.

On Jul, 20, 2026

29 people who take Zide and Irinotecan hydrochloride together, and have interactions are studied.

Zide and Irinotecan hydrochloride drug interactions.

What are the common drug interactions of Zide and Irinotecan Hydrochloride, by gender? *:

female:

Febrile neutropenia (fever with reduced white blood cells)
Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Hypokalaemia (low potassium)
Pneumonia
Dehydration (dryness resulting from the removal of water)
Hypotension (abnormally low blood pressure)
Diarrhoea
Death
General physical health deterioration (weak health status)

male:

Neutropenia (an abnormally low number of neutrophils)
Blood creatinine increased
Febrile neutropenia (fever with reduced white blood cells)
Herpes zoster
Mucosal inflammation (infection of mucous membrane)
Perioral dermatitis (facial rash that causes bumps to develop around the mouth)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Rash
Rectal haemorrhage (bleeding from anus)

What are the common drug interactions of Zide and Irinotecan Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pneumonia

50-59:

Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Diarrhoea
Neutropenia (an abnormally low number of neutrophils)
Acute hepatic failure
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)

60+:

Febrile neutropenia (fever with reduced white blood cells)
Anaemia (lack of blood)
Enteritis (inflammation of the small intestine)
General physical health deterioration (weak health status)
Head injury
Infection
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)
Peripheral ischaemia (impaired circulation to an extremity)

What are the existing conditions these people have? *

Colon Cancer: 8 people, 27.59%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 5 people, 17.24%
Weakness: 2 people, 6.90%
Type 2 Diabetes: 2 people, 6.90%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 2 people, 6.90%
Oesophageal Cancer Metastatic (cancer of oesophagues spreads to other part): 2 people, 6.90%
Metastatic Gastric Cancer (cancer types can spread to the stomach from other place): 2 people, 6.90%
Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 2 people, 6.90%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 2 people, 6.90%
Gastrointestinal Carcinoma (cancer of stomach or intestine): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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