Zofran and Creatine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Creatine (creatine). Common drug interactions include malaise among females and catheter site pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Creatine. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Creatine?

Creatine has active ingredients of creatine. It is often used in muscle mass. eHealthMe is studying from 1,390 Creatine users. Check the latest studies of Creatine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

17 people who take Zofran and Creatine together, and have interactions are studied.

What are the common drug interactions of Zofran and Creatine, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Viral infection
Blood pressure increased
Headache (pain in head)
Influenza
Ear infection
Infection
Upper respiratory tract infection
Abdominal pain upper
Administration site pain

male:

Catheter site pain
Device related infection
Hepatitis acute
Liver injury
Weight decreased

What are the common drug interactions of Zofran and Creatine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Catheter site pain
Device related infection

20-29:

Weight decreased
Abdominal pain upper
Administration site pain
Arthralgia (joint pain)
Contusion (a type of hematoma of tissue in which capillaries)
Device related infection
Fatigue (feeling of tiredness)
Impaired gastric emptying
Post-traumatic stress disorder
Sleep disorder

30-39:

Asthma
Blood pressure increased
Breast mass
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Ear infection
Food poisoning (poison in food)
Headache (pain in head)
Idiopathic intracranial hypertension (elevated cerebrospinal fluid pressure of unknown cause)
Infection
Influenza

40-49:

Food poisoning (poison in food)
Headache (pain in head)
Influenza
Laryngitis (inflammation of the larynx)
Malaise (a feeling of general discomfort or uneasiness)
Sinusitis (inflammation of sinus)
Viral infection
Ear infection
Infection
Upper respiratory tract infection

50-59:

Back pain
Dyspnoea (difficult or laboured respiration)
Muscle atrophy (a decrease in the mass of the muscle)
Myopathy (a muscular disease in which the muscle fibres do not function)
Neuralgia (pain in one or more nerves)
Neuropathy peripheral (surface nerve damage)
Sinusitis (inflammation of sinus)

60+:

n/a

What are the existing conditions these people have? *

Myopathy (a muscular disease in which the muscle fibres do not function): 6 people, 35.29%
Stiff Person Syndrome: 5 people, 29.41%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 5 people, 29.41%
Renal Cell Carcinoma (a kidney cancer): 2 people, 11.76%
Nausea And Vomiting: 2 people, 11.76%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 2 people, 11.76%
Cough: 2 people, 11.76%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 11.76%
Weight Loss: 1 person, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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