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Zoloft and Absorica drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Absorica (isotretinoin). Common drug interactions include premature delivery among females and suicidal ideation among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Absorica. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Absorica?

Absorica has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 2,556 Absorica users. Check the latest studies of Absorica.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

12 people who take Zoloft and Absorica together, and have interactions are studied.

Zoloft and Absorica drug interactions.

What are the common drug interactions of Zoloft and Absorica, by gender? *:

female:

  1. Premature delivery
  2. Abortion induced (medically referred abortion)
  3. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  4. Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
  5. Suicidal ideation

male:

  1. Suicidal ideation
  2. Anger
  3. Panic attack
  4. Vision blurred
  5. Arthralgia (joint pain)
  6. Crying
  7. Disturbance in attention
  8. Dizziness
  9. Fear
  10. Headache (pain in head)

What are the common drug interactions of Zoloft and Absorica, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Suicidal ideation

20-29:

  1. Premature delivery
  2. Abortion induced (medically referred abortion)
  3. Migraine (headache)
  4. Nausea (feeling of having an urge to vomit)
  5. Panic attack
  6. Vision blurred
  7. Anger
  8. Arthralgia (joint pain)
  9. Crying
  10. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Acne Cystic (skin problems that cause pimples): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and Absorica?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zoloft and Absorica:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Absorica:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zoloft and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Absorica and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride and isotretinoin (the active ingredients of Zoloft and Absorica, respectively), and Zoloft and Absorica (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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