Zoloft and Amrix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Amrix (cyclobenzaprine hydrochloride). Common drug interactions include heart rate decreased among females and blood cholesterol increased among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Amrix. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Amrix?

Amrix has active ingredients of cyclobenzaprine hydrochloride. It is often used in back pain. eHealthMe is studying from 1,130 Amrix users. Check the latest studies of Amrix.

On Jul, 09, 2026

47 people who take Zoloft and Amrix together, and have interactions are studied.

What are the common drug interactions of Zoloft and Amrix, by gender? *:

female:

Heart rate decreased
Hepatic steatosis (fatty liver disease)
Hospitalisation
Hypercalciuria (elevated calcium (ca+) level in the urine)
Suicide attempt
Abdominal discomfort
Disability
Intervertebral disc protrusion (spinal disc protrusion)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Overdose

male:

Blood cholesterol increased
Cardiac disorder
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Injury
Memory impairment
Multiple injuries
Renal injury (kidney injury)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Zoloft and Amrix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Suicide attempt
Overdose
Abdominal pain
Agitation (state of anxiety or nervous excitement)
Anger
Asthenia (weakness)
Constipation
Depressed mood
Disturbance in attention
Dizziness

40-49:

n/a

50-59:

Fall
Suicidal ideation
Activities of daily living impaired
Arthralgia (joint pain)
Arthropathy
Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
Blood potassium decreased
Dry mouth
Foot deformity (functional disability of foot)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)

60+:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Pulmonary oedema (fluid accumulation in the lungs)
Rash
Blood cholesterol increased
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Joint swelling
Loss of consciousness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 29 people, 61.70%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 29 people, 61.70%
Stress And Anxiety: 5 people, 10.64%
Insomnia (sleeplessness): 5 people, 10.64%
Hot Flush (sudden feelings of heat): 3 people, 6.38%
Drowsiness: 3 people, 6.38%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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