Zoloft and Androderm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Androderm (testosterone). Common drug interactions include application site pruritus among females and coronary artery disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Androderm. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Androderm?

Androderm has active ingredients of testosterone. It is often used in testosterone. eHealthMe is studying from 4,115 Androderm users. Check the latest studies of Androderm.

On Jul, 16, 2026

23 people who take Zoloft and Androderm together, and have interactions are studied.

What are the common drug interactions of Zoloft and Androderm, by gender? *:

female:

Application site pruritus (application site severe itching of the skin)

male:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Activated partial thromboplastin time prolonged
Acute myocardial infarction (acute heart attack)
Alanine aminotransferase increased
Anaemia (lack of blood)
Asthenia (weakness)
Blood creatine phosphokinase mb increased
Blood urine present
Cardiomyopathy (weakening of the heart muscle)

What are the common drug interactions of Zoloft and Androderm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Application site pruritus (application site severe itching of the skin)

20-29:

n/a

30-39:

Application site reaction

40-49:

n/a

50-59:

Inflammation
Lethargy (tiredness)
Libido decreased (loss of interest in sex)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Lung nodule (solid, raised areas in lung)
Lymphadenopathy (disease or enlargement of lymph nodes)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Mastoiditis (infection of mastoid bone)
Memory impairment
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Acute myocardial infarction (acute heart attack)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Intracardiac thrombus (presence of a circumscribed mass with heart wall)
Pulmonary embolism (blockage of the main artery of the lung)
Agitation (state of anxiety or nervous excitement)
Application site erythema (redness of the skin at application site)
Application site pain
Application site pruritus (application site severe itching of the skin)
Blood pressure systolic increased

What are the existing conditions these people have? *

Pain: 6 people, 26.09%
Inflammation: 4 people, 17.39%
Type 2 Diabetes: 3 people, 13.04%
High Blood Cholesterol: 3 people, 13.04%
Stress And Anxiety: 3 people, 13.04%
Bladder Disorder: 2 people, 8.70%
Blood Testosterone Decreased: 2 people, 8.70%
Calcium Deficiency (lack of calcium): 2 people, 8.70%
Fatty Acid Deficiency: 2 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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