Zoloft and Ascorbate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Ascorbate (vitamin c (ascorbic acid)). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Ascorbate. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,801 Zoloft users. Check the latest studies of Zoloft.

What is Ascorbate?

Ascorbate has active ingredients of vitamin c (ascorbic acid). eHealthMe is studying from 1,446 Ascorbate users. Check the latest studies of Ascorbate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

30 people who take Zoloft and Ascorbate together, and have interactions are studied.

What are the common drug interactions of Zoloft and Ascorbate, by gender? *:

female:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Infusion related reaction
Malaise (a feeling of general discomfort or uneasiness)
Vomiting
Pain
Cellulitis (infection under the skin)
Concussion (short loss of normal brain function in response to a head injury)
Head injury
Alopecia (absence of hair from areas of the body)

male:

n/a

What are the common drug interactions of Zoloft and Ascorbate, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Fatigue (feeling of tiredness)

50-59:

Weight increased
Blood creatine phosphokinase increased
Blood iron decreased
Pain
Red blood cell sedimentation rate increased
Vitamin b12 increased
Vitamin d decreased
Abdominal pain upper
Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)

60+:

Nausea (feeling of having an urge to vomit)
Fall
Feeding disorder (when children refuse to eat certain food groups)
Head injury
Infusion related reaction
Malaise (a feeling of general discomfort or uneasiness)
Vomiting
Weight increased
Pain
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 23.33%
Immunodeficiency Common Variable: 7 people, 23.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 23.33%
Stress And Anxiety: 5 people, 16.67%
Seasonal Allergy (allergic condition due to certain season): 4 people, 13.33%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 13.33%
Neuralgia (pain in one or more nerves): 4 people, 13.33%
Joint Pain: 4 people, 13.33%
Insomnia (sleeplessness): 4 people, 13.33%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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