Zoloft and Claritin-d drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Claritin-d (loratadine; pseudoephedrine sulfate). Common drug interactions include scar among females and oedema peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Claritin-d. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,801 Zoloft users. Check the latest studies of Zoloft.

What is Claritin-d?

Claritin-d has active ingredients of loratadine; pseudoephedrine sulfate. It is often used in allergies. eHealthMe is studying from 7,055 Claritin-d users. Check the latest studies of Claritin-d.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

55 people who take Zoloft and Claritin-d together, and have interactions are studied.

Zoloft and Claritin-d drug interactions.

What are the common drug interactions of Zoloft and Claritin-D, by gender? *:

female:

Scar
Chondropathy (disease of the cartilage)
Insomnia (sleeplessness)
Pain
Pneumonia
Asthenia (weakness)
Fall
Pain in extremity
Urinary tract infection
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Oedema peripheral (superficial swelling)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Cataract (clouding of the lens inside the eye)
Neuropathy peripheral (surface nerve damage)
Spinal compression fracture (fracture due to spinal compression on bone)
Upper respiratory tract infection
Asthenia (weakness)
Blood albumin decreased

What are the common drug interactions of Zoloft and Claritin-D, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Lower respiratory tract infection viral
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Nausea (feeling of having an urge to vomit)
Pain

30-39:

Blood pressure systolic increased
Colitis ulcerative (inflammation of colon with ulcer)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Headache (pain in head)
Micturition urgency (urgency to pass the urine)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

40-49:

Scar
Infusion site induration
Salmonellosis (an infection with salmonella bacteria)
Sinusitis (inflammation of sinus)
Back pain
Fall
Malaise (a feeling of general discomfort or uneasiness)
Pain in extremity
Urinary tract infection
Abdominal discomfort

50-59:

Enteritis (inflammation of the small intestine)
Epigastric discomfort
Eye discharge
Facial pain
Frequent bowel movements
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gingival bleeding (bleeding gums)
Gingival erosion (gum ulcer)
Gingival hypertrophy (overgrowth of gums)
Gingival pain (gum pain)

60+:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Neuropathy peripheral (surface nerve damage)
Sinusitis (inflammation of sinus)
Spinal compression fracture (fracture due to spinal compression on bone)
Upper respiratory tract infection
Blood albumin decreased
Blood glucose increased
Blood pressure increased
Cholecystitis (infection of gallbladder)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 21.82%
Stress And Anxiety: 5 people, 9.09%
Seasonal Allergy (allergic condition due to certain season): 5 people, 9.09%
Nausea (feeling of having an urge to vomit): 5 people, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 9.09%
Back Pain: 5 people, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 9.09%
Type 2 Diabetes: 4 people, 7.27%
Pain: 4 people, 7.27%

* Approximation only. Some reports may have incomplete information.

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