Zoloft and Estring drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Estring (estradiol). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Estring. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,801 Zoloft users. Check the latest studies of Zoloft.

What is Estring?

Estring has active ingredients of estradiol. eHealthMe is studying from 5,474 Estring users. Check the latest studies of Estring.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

70 people who take Zoloft and Estring together, and have interactions are studied.

What are the common drug interactions of Zoloft and Estring, by gender? *:

female:

Drug ineffective
Pain
Hip fracture
Intestinal obstruction
Nervousness
Panic attack
Seborrhoeic dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp)
Upper respiratory tract infection
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough

male:

n/a

What are the common drug interactions of Zoloft and Estring, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Gastric bypass
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

50-59:

Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Endocrine disorder (endocrine diseases are disorders of the endocrine system)
Erythema (redness of the skin)
Facial nerve disorder (disease of face nerve)
Fatigue (feeling of tiredness)
General physical condition
Inflammatory bowel disease
Insomnia (sleeplessness)

60+:

Drug ineffective
Accident
Dyspnoea (difficult or laboured respiration)
Fungal oesophagitis (fungal inflammation of the oesophagus)
Throat irritation
Pain
Fall
Rash
Abdominal pain upper
Activities of daily living impaired

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 35 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 28 people, 40.00%
Urinary Tract Infection: 7 people, 10.00%
Thyroid Diseases: 7 people, 10.00%
Pain: 6 people, 8.57%
Atrophic Vulvovaginitis (inflammation of the vulva): 6 people, 8.57%
Stress And Anxiety: 5 people, 7.14%
Sleep Disorder: 5 people, 7.14%
Hypersensitivity: 4 people, 5.71%
Dizziness: 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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