Zoloft and Flecainide acetate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Flecainide acetate (flecainide acetate). Common drug interactions include paraesthesia among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Flecainide acetate. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Flecainide acetate?

Flecainide acetate has active ingredients of flecainide acetate. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 7,176 Flecainide acetate users. Check the latest studies of Flecainide acetate.

On Jul, 07, 2026

91 people who take Zoloft and Flecainide acetate together, and have interactions are studied.

Zoloft and Flecainide acetate drug interactions.

What are the common drug interactions of Zoloft and Flecainide Acetate, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Skin discolouration (change of skin colour)
Skin hypopigmentation (loss of skin colour)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Hypertension (high blood pressure)
Joint swelling
Lower extremity mass (mass in lower legs)
Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

male:

Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Diastolic dysfunction
Joint swelling
Splenomegaly (enlargement of spleen)
Thrombocytopenia (decrease of platelets in blood)
Blood urea increased
Cardiomegaly (increased size of heart than normal)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

What are the common drug interactions of Zoloft and Flecainide Acetate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Heart rate irregular
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)

30-39:

Abdominal pain
Blood pressure increased
Nausea (feeling of having an urge to vomit)
Weight decreased
Dyspnoea (difficult or laboured respiration)
Gastrointestinal viral infection (virus infection of gastrointestinal tract)
Heart rate irregular
Nasopharyngitis (inflammation of the nasopharynx)
Palpitations (feelings or sensations that your heart is pounding or racing)
Presyncope

40-49:

Pain
Emotional distress
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
General physical health deterioration (weak health status)
Injury
Joint swelling
Lower extremity mass (mass in lower legs)
Mobility decreased (ability to move is reduced)
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

50-59:

Heart rate increased
Hyperthyroidism (over activity of the thyroid gland)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Rash macular (small, flat red spots)
Blood glucose decreased
Blood glucose increased

60+:

International normalised ratio increased
Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Asthenia (weakness)
Overdose
Quality of life decreased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Diastolic dysfunction
Joint swelling

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 18.68%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 7.69%
Immunodeficiency Common Variable: 6 people, 6.59%
Urinary Tract Infection: 5 people, 5.49%
Osteoporosis (bones weak and more likely to break): 5 people, 5.49%
High Blood Cholesterol: 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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